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Deep Limbic System Thalamus (DLS)
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| DLS Functions | DLS Problems | Some Conditions Affecting the DLS | ||||
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Mood control   |
Depression |
Depression |
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DLS Treatments Meds to increase norepinephrine/dopamine/serotonin |
DLS Meds Depression |
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Increased activity in the DLS is often associated with depression, dysthymia and negativity. Left-sided problems are often associated with anger and irritability, right sided problems more often associated with inwardly directed sadness. In our experience we have seen diffuse DLS overactivity tends to be more consistent depression and focal increased DLS activity (more on one side than the other) to be associated with cyclic mood disorders. When focal increased uptake is found in conjunction with patchy increased uptake across the cortical surface there is a higher likelihood of a cyclothymic or bipolar disorder. If clinically indicated, diffuse increased DLS uptake is often helped by antidepressant medications. If there is also increased anterior cingulate activity consider a serotonergic antidepressant. If there is not increased anterior cingulate activity consider an antidepressant which increases either dopamine (such as buprion) or norepinephrine (such as imipramine or desipramine).  We use anticonvulsants or lithium to help with focal DLS hyperactivity when a cyclic mood clinical pattern is present. We have also seen increased activity in this part of the brain in our normal population. Clinical correlation is needed.Â
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