Amen Clinics Home
Call Today!
(888) 564-2700

Monthly Archives: April 2008

Change Your Diet, Change Your Brain

In a landmark study from Holland researchers found that putting children on elimination diets significantly improved ADD symptoms.  The abstract is below.

Eur Child Adolesc Psychiatry. 2008 Apr 21 A randomised controlled trial into the effects of food on ADHD.Pelsser LM, Frankena K, Toorman J, Savelkoul HF, Pereira RR, Buitelaar JK.ADHD Research Centre, Liviuslaan 49, 5624 JE, Eindhoven, The Netherlands 

The aim of this study is to assess the efficacy of a restricted elimination diet in reducing symptoms in an unselected group of children with Attention deficit/hyperactivity disorder (ADHD). Dietary studies have already shown evidence of efficacy in selected subgroups.

Twenty-seven children (mean age 6.2) who all met the DSM-IV criteria for ADHD, were assigned randomly to either an intervention group (15/27) or a waiting-list control group (12/27). Primary endpoint was the clinical response, i.e. a decrease in the symptom scores by 50% or more, at week 9 based on parent and teacher ratings on the abbreviated ten-item Conners Scale and the ADHD-DSM-IV Rating Scale.

The intention-to-treat analysis showed that the number of clinical responders in the intervention group was significantly larger than that in the control group [parent ratings 11/15 (73%) versus 0/12 (0%); teacher ratings, 7/10 (70%) versus 0/7 (0%)]. The Number of ADHD criteria on the ADHD Rating Scale showed an effect size of 2.1 (cohen’s d) and a scale reduction of 69.4%. Comorbid symptoms of oppositional defiant disorder also showed a significantly greater decrease in the intervention group than it did in the control group (cohens’s d 1.1, scale reduction 45.3%).

A strictly supervised elimination diet may be a valuable instrument in testing young children with ADHD on whether dietary factors may contribute to the manifestation of the disorder and may have a beneficial effect on the children’s behaviour.

5HTP As A Potential Treatment for Sleep Terrors

Sleep terrors, also called night terrors, are a very disturbing problem in children and adults.  They are characterized by extreme terror and a temporary inability to regain full consciousness.  The person may wake abruptly from sleep and be accompanied by gasping, moaning or screaming.  It is very difficult to fully awaken the person. 

Here is a fasinating study showing 5HTP as a potentially effective treatment.

Eur J Pediatr. 2004 Jul;163(7):402-7. Epub 2004 May 14. L -5-Hydroxytryptophan treatment of sleep terrors in children.  Bruni O, Ferri R, Miano S, Verrillo E.  Centre for Paediatric Sleep Disorders, Department of Developmental Neurology and Psychiatry, University of Rome “La Sapienza”, Via dei Sabelli 108, 00185 Rome, Italy.

To test the hypothesis that the administration of L -5-hydroxytryptophan (L -5-HTP) might exert beneficial effects on sleep terrors, we carried out an open pharmacological trial in a group of children with sleep terrors compared to a group of children with the same disorder but without L -5-HTP treatment. Participants in the trial were 45 children (34 males and 11 females; age range 3.2-10.6 years), referred to the Sleep Centre of the Department of Developmental Neurology and Psychiatry of the University of Rome “La Sapienza”, affected by sleep terrors. All subjects underwent: (1) complete medical and sleep history; (2) complete neurological examination and EEG recording whilst awake and sleeping, (3) a structured sleep diary for 2 months, (4) after 1 month, all subjects were examined again from the clinical and EEG points of view and (5) after 6 months, a structured interview in order to evaluate the clinical outcome. After the first visit, L -5-HTP was administered (2 mg/kg per day) at bedtime to 31 randomly selected patients for a single period of 20 consecutive days. After 1 month of treatment, 29/31 (93.5%) of patients showed a positive response. In the comparison group without drug therapy, after 1 month, the episodes disappeared only in four children (28.6%) while ten children (71.4%) showed the persistence of episodes with the same frequency as before. After 6 months, 26/31 (83.9%) of children treated with L -5HTP were sleep terror-free, while in five children (16.1%) sleep terror episodes persisted. Of the children in the comparison group, ten (71.4%) continued to show sleep terrors at 6-month follow-up. CONCLUSION: to our knowledge, this is the first study demonstrating the efficacy of a new drug treatment for sleep terrors. These results confirm our initial hypothesis and represent evidence that treatment with L -5-hydroxytryptophan is able to modulate the arousal level in children and to induce a long-term improvement of sleep terrors.

We all need some anxiety

Can some anxiety be good?  Of course! Anxiety is what prevents you from driving 125 miles per hour down the freeway in the rain.  Anxiety prevents you from giving someone you just met in the bar your home phone number.  Remember the movie Fatal Attraction? 

I think I have been a fairly anxious person most of my life.  When I was little I had an older brother who pounded me on a regular basis, which may have set up a sense in my brain that something bad is about to happen.  I used to bite my finger nails and often carried a lot of tension in my shoulders.  But anxiety is not all bad. 

After medical school I went back into the Army as an officer so I could do my psychiatry training at Walter Reed in Washington, DC.  But first I had to go to several weeks of officer training school at Fort Sam Houston in Texas.  One day we were doing a ropes course.  We had to traverse a ravine, hand over hand using a rope anchored to each end.  It was about fifty feet across and 30 feet above a dry rock bed.  The physical part didn’t bother me.  But they tied us to the rope with a Swiss seat, a rope around our waist and through our legs.  When we got out into the middle of the ravine we were instructed to let go and let the Swiss seat hold us up.  For some reason I did not trust it.  When I got out into the middle of the ravine I did not want to let go.  I felt like a scared little bunny rabbit.  I knew my friends would be laughing at me and it caused quite an internal crisis.  But that day the scared bunny rabbit won. I didn’t let go and scurried to the other side.  With my friends razzing me I climbed up on the other side of the ravine only to turn around and see my best friend at the course let go of the rope.  They had mistied his Swiss seat and I watched him fall 30 feet to the rocks below, where he broke his neck and punctured his lungs.  From that moment on I have been grateful for my anxiety.  It often helps prevent bad things from happening. 

Clearly some anxiety is good, but what can you do when it gets out of control.  As in ADD, depression and bipolar disorder, there are different types of anxiety disorders, so knowing which type you have is essential to getting the best treatment.  Certain medications and supplements can be very helpful. With anxiety disorders I tend to use supplements first because I do not like what I have seen on scans.  Some of the anti-anxiety medications, like Xanax, work like alcohol on the brain.  Supplements such as 5-HTP, GABA, kava kava and green tea have been found to be helpful.  Plus, I really like hypnosis, guided imagery and meditation to calm anxiety and teaching people how to rid themselves of the anxious ANTs that provide the seeds of anxiety disorders.

Forgotten Head Trauma May Ruin Your Life

ABC in Washington, DC did a story on our work.  Forgotten head trauma can ruin your life.  Check out this video.  Also, I usually think tennis is a relatively safe sport, but not for some people who lack impulse and anger control. I bet his scan before the injury was not among the healthiest.

http://www.wjla.com/news/stories/0408/508342.html

http://sportsillustrated.cnn.com/2008/tennis/04/02/bc.ten.bloodiedyouzhny.ap/index.html?cnn=yes

Also, due to the success of the PBS special, Change Your Brain, Change Your Life hit the New York Times bestseller list for the second straight week.

DanielÂ