Type 2: Pure Depression


This type of depression is associated with primary depressive symptoms that range from chronic mild sadness (also known as “dysthymia”) to the devastating illness of major depression. The hallmark symptoms of Pure Depression include:

  • Persistent sad or negative mood
  • Loss of interest in usually pleasurable activities
  • Periods of crying
  • Frequent feelings of guilt, helplessness, hopelessness, or worthlessness
  • Changes in sleep and appetite patterns and habits
  • Low energy levels
  • Low self-esteem
  • Suicidal thoughts or attempts


  • Noticeable increased activity in the deep limbic area while the person is at rest and while the person is concentrating
  • Decreased prefrontal cortex activity at rest that improves with concentration
  • Deactivation of the prefrontal cortex at rest and improvement with concentration (less common).