Schizophrenia and Schizoaffective Disorders

Unlike traditional psychiatry, which rarely looks at the brain, Amen Clinics uses brain imaging technology to help identify underlying brain issues associated with schizophrenia and schizoaffective disorders.

What are Schizophrenia and Schizoaffective Disorders?

Schizophrenia and schizoaffective disorder affect a person’s ability to distinguish reality from what is not real. Schizophrenia is a chronic, long-standing disorder characterized by delusions, hallucinations, and distorted thinking. People with schizoaffective disorder have symptoms of schizophrenia as well as symptoms of mood disorders, such as depression or mania. These disorders are complex and involve several brain areas.

Who is Affected by Schizophrenia?

Schizophrenia affects about 1% of the U.S. population and schizoaffective disorders affect about 0.3% of Americans. Symptoms associated with schizophrenia are more likely to develop during a man’s late teens to early 20s and a woman’s late 20s to early 30s. It is rare for schizophrenia to occur in children or to develop in people after the age of 40.

What are the Symptoms?

Schizophrenia is a chronic, long-standing disorder characterized by delusions, hallucinations, and distorted thinking. Symptoms of schizophrenia are grouped into three categories: positive (things outside of normal mental functioning that may start happening), negative (things that may stop happening), and cognitive.

Positive Symptoms: Includes Hallucinations (hearing voices, seeing people, or feeling tactile sensations that aren’t there), delusions, agitated body movements, disorganized thinking

Negative Symptoms: Decreased sense of pleasure in life, Trouble starting and following through with activities, difficulty maintaining relationships, speaking less and feeling emotionally flat

Cognitive Symptoms: Decreased executive function (processing incoming information, decision-making), difficulty with concentration and focus, trouble with memory, unawareness that they have a disorder/condition.

What Causes It?

Research suggests that are several possible causes of the condition, including:

  • Genetics: The condition tends to run in families, which means there is a genetic component.
  • Brain chemistry abnormalities: Problems with neurotransmitters may contribute to schizophrenia.
  • Substance use: Research suggests that using psychoactive drugs, including using marijuana as a teen or young adult increases the risk of developing schizophrenia.
  • Environmental factors: Other possible causes include exposure to infections, autoimmune diseases, inflammation, psychosocial factors, problems during birth, or malnutrition prior to birth.

Consequences of untreated schizophrenia & schizoaffective disorders include:

Why Choose Amen Clinics for Treating Schizophrenia and Schizoaffective Disorder?

Schizophrenia is often misdiagnosed for a variety of reasons. At Amen Clinics, we use brain SPECT imaging as part of a comprehensive assessment to diagnose and treat our patients. We also assess other factors—biological, psychological, social, and spiritual—that can contribute to symptoms of schizophrenia and schizoaffective disorder. Based on all of this information, we are able to personalize treatment using the least toxic, most effective solutions for a better outcome.

Contact Us

Schizophrenic Brains Work Differently

These disorders are complex and involve several brain areas. Abnormalities in the neurotransmitters dopamine and glutamate—and possibly others—cause decreased activity in the prefrontal cortex (the area of the brain involved in decision-making, judgment, forethought, attention, impulse control, and more). Brain SPECT imaging studies on people with schizophrenia and schizoaffective disorder show why incoming information is distorted.

Healthy Brain Scan

Schizophrenic Brain Scan

SPECT (single photon emission computed tomography) is a nuclear medicine study that evaluates blood flow and activity in the brain. Basically, it shows three things: healthy activity, too little activity, or too much activity. The healthy surface brain SPECT scan on the left shows full, even symmetrical activity. The brain scan on the right from a man named Steve with schizophrenia (read more about Steve below) shows high levels of damage and overall decreased activity.

Ready to learn more? Speak to a care coordinator today!

Contact Us

Schizophrenia & Schizoaffective Disorder: Links to Other Conditions

Emerging scientific evidence shows that schizophrenia and schizoaffective disorders are linked to other conditions and issues, including the following.

Link Between Schizophrenia and Lyme Disease

Many people with resistant psychiatric conditions, such as schizophrenia and schizoaffective disorder, have been exposed to infectious agents that damaged their brains. In 1994, the Schizophrenia Bulletin published an image comparing the areas of the United States with the highest rates of Lyme disease and schizophrenia. They were nearly identical.

At Amen Clinics, we’ve treated hundreds of patients who came to us with resistant psychiatric symptoms, tested positive for Lyme disease, and were helped by treating it. A 2014 study reported that the antibiotic minocycline, used to treat Lyme disease, was found to decrease symptoms of schizophrenia in a 12-month period.

Link Between Schizophrenia and Other Infections

Other infections also have a connection to schizophrenia and other conditions. In an important study from Denmark, patients who had infections, even those that did not require hospitalization, had a higher incidence of schizophrenia and depression. Infections that have been linked to schizophrenia include:

  • Strep
  • Mycoplasma pneumonia
  • Herpes simplex
  • Toxoplasma gondii—a tiny single-celled parasite that is often carried in cats and shed in their feces
  • Fungal infections

Link Between Schizophrenia and Autoimmune Disease

Many autoimmune illnesses are linked with psychiatric issues. For example, having an autoimmune disease is associated with a 45% increased risk for schizophrenia. Researchers are still trying to pinpoint the exact causes of autoimmune disorders, but many factors can play a role in their development, including:

  • Leaky gut
  • Environmental allergens—pollen, dust mites, mold
  • Food allergens—dairy, eggs, fish, shellfish, tree nuts, peanuts, wheat, and soybeans are the top 8, according to the FDA
  • Toxins
  • Obesity
  • Head trauma
  • Lack of exercise or excessive exercise
  • Poor diet
  • Nutrient deficiencies
  • Stress
  • Sleep disorders

Link Between Schizophrenia and Gluten

Gluten sensitivity and celiac disease are related to a number of psychiatric disorders and symptoms, including schizophrenia. A growing body of evidence suggests that nutritional treatment may help prevent, treat, or improve schizophrenia, schizoaffective disorder, and other conditions, such as depression, bipolar disorder, anxiety, ADHD, autism, and addiction. Adopting a gluten-free diet has been associated with improvements in people with mental health conditions. Research found a decrease, or even full remission, of symptoms in a subset of patients with schizophrenia.


“With A Better Brain Comes A Better Life”

– Daniel G. Amen, M.D.


How Steve Healed from Schizophrenia

Steve’s mother brought him to Amen Clinics. Steve was homeless on the streets of San Francisco and had been diagnosed with paranoid schizophrenia and drug abuse but refused to take any medicine. He was so aggressive that he could not live at home. He was clearly psychotic when he came to our clinic and his first comment was, “I’m not going to take medicine, and you can’t make me.” He had experienced a bad reaction to medications in the past.

We told him we didn’t want him to do anything he didn’t want to do but asked if we could look at his brain, which he agreed to do. Of the more than 200,000 functional brain scans we have at Amen Clinics, Steve’s scan was one of the worst we had ever seen, with overall low activity. (See Steve’s scan above.) When he saw it he just stared at it for about 5 minutes, then asked, “Can you help me?”

We told him that there were better medications than the ones he had tried before and put him on a newer antipsychotic medication and gave him an appointment for 3 weeks later. A week later, Steve’s mother showed up in our clinic and said, “You cannot believe how much better Steven is. He is not hallucinating as much and is calmer, and we can have him live at home.”

When Steve came in for his 3-week follow-up visit, he was so apologetic for being difficult and said he felt so much better. His scan was also remarkably better as well. In less than one month, his brain was better.

Contact Us