How Anti-Anxiety Pills Increase Dementia
When the anti-anxiety medications benzodiazepines hit the market in the mid-20th century, they earned the nickname, “mommy’s little helper.” The Rolling Stones even wrote a song entitled “Mother’s Little Helper” in 1966 that included these lyrics:
Mother needs something today to calm her down
And though she’s not really ill, there’s a little yellow pill
She goes running for the shelter of her mother’s little helper
And it helps her on her way, gets her through her busy day
The song made reference to a little yellow pill, Valium, which remains one of the most commonly prescribed brands of benzodiazepines. Other widely used brands include Xanax, Ativan, and Klonopin.
But research shows that “mommy’s little helper” can steal mommy’s mind.
Scientists have long known that long-term use of benzodiazepines for the treatment of anxiety disorders or panic disorder can increase the risk of cognitive impairment or dementia later in life. A 2022 study in Nature Neuroscience provides new insights into how these drugs impact brain function, and it’s frightening. According to the researchers, benzodiazepines damage microglial cells, which then interfere with the synaptic connections that allow parts of the brain to communicate with other regions. When communication is disrupted, cognitive decline can occur.
Research shows that “mommy’s little helper” can steal mommy’s mind. Anti-anxiety medications can increase the risk of cognitive impairment or dementia later in life.
INCREASED USE OF ANTI-ANXIETY PILLS
This is extremely disturbing considering the increased use of such drugs. An estimated 66 million doctor appointments annually result in prescriptions for benzodiazepines, according to a report from the U.S. Department of Health and Human Services. This means that for every 100 adults who go to a doctor’s office visit, 27 will leave with a prescription for a benzodiazepine. Those numbers are getting even higher. A report released in 2020 pointed to a 34% increase in the number of anti-anxiety medication prescriptions filled during the pandemic. An even higher number, 38%, represented new prescriptions filled for benzodiazepines. This could signal a rising tsunami of dementia in the future.CONSEQUENCES OF USING ANTI-ANXIETY MEDICATIONS
When you have anxiety or a panic attack, it can make you feel awful—nervous, fearful, jittery, breathless, and out of control. It’s no wonder people want fast relief and turn to quick fixes like benzodiazepines that can be prescribed by a primary care physician in a brief office visit. But the short-term benefits of anti-anxiety medications come with serious long-term consequences.- Damage to brain function: The brain SPECT imaging used at Amen Clinics shows the negative impacts of anti-anxiety medications on the brain. SPECT is a nuclear medicine study that measures blood flow and activity in the brain. Basically, it shows 3 things: areas with healthy activity, too much activity, or too little activity. As far back as 1991, when Dr. Amen first began using SPECT imaging in clinical psychiatric practice, it became clear that benzodiazepines decrease brain activity and have a toxic effect on the brain. Toxic brains look shriveled or have a scalloped effect, which is an indicator of low activity. According to the 2022 study mentioned earlier, benzodiazepines also interfere with the brain’s ability to communicate effectively.
- Dependence and addiction: For many people, it can be difficult to stop taking anti-anxiety medications. In some people, it can lead to physical dependence or addiction. Be careful not to start taking medication that is hard to stop.
- Memory loss and dementia: As mentioned earlier, taking anxiety pills over a long period of time raises the risk of cognitive decline. According to a 2019 analysis of 10 studies, long-term use of benzodiazepines raised the likelihood of developing dementia by more than 50%.
- Accidental overdose: Taking benzodiazepines in addition to drinking alcohol or using sleep aids can result in an overdose that can be fatal in some instances.
- Suicidal behavior: Research shows that taking benzodiazepines is associated with an increased risk of suicide attempts and death by suicide.




