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13 Positive Affirmations to Boost Moods and Build Mental Strength

45 Positive Affirmations to Overcome Uncomfortable Emotions
Daily affirmations can be a powerful way to heal and build emotional and mental health when you’re feeling bad.

If you’ve ever felt held back by anxiety, anger, or self-doubt, or you’ve been haunted by past trauma you can’t seem to shake, you’re not alone. The brain holds onto these memories and thought patterns, which makes it challenging to move forward.

Emotional issues are tightly linked to brain function, according to over 250,000 brain scans at Amen Clinics. SPECT scans reveal abnormal activity in various brain regions—such as the basal ganglia and limbic system—in people who struggle with anxiety disorders, anger issues, post-traumatic stress disorder (PTSD), and other mental health conditions.

Positive affirmations offer a practical way to ease the hold of negative thoughts, calm anxiety, and strengthen mental resilience. And scientific research shows that they can help rewire the brain in beneficial ways.

Daily affirmations can be a powerful way to heal and build emotional and mental health when you’re feeling bad. In this blog, you’ll discover 45 affirmations you can say to enhance your brain and help you cope with 10 of the most common negative emotions.

HOW POSITIVE AFFIRMATIONS HELP OVERCOME NEGATIVE EMOTIONS

1. When You’re Feeling Anxious

Anxiety often presents itself when past fears or trauma resurfaces. Oftentimes, it’s triggered by familiar sights, sounds, or social interactions. There are simple anxiety-soothing techniques to help you calm your mind. Pair these with daily positive affirmations to help calm anxiety and enhance your sense of safety.

Positive Affirmations:

  • I am safe.
  • I am secure.
  • I am calm.
  • I am protected.
  • I focus on my breathing and centering myself.

2. When You’re Feeling Angry

Old wounds or disappointments can be triggered by previous shame, guilt, bullying, abuse, or resentment. Anger can be constructive; however, in excess and unchecked, it is incredibly destructive.

Learning healthy ways to release your anger helps build resilience and strengthen cognitive well-being throughout your life.

Positive Affirmations:

  • I express my anger in ways others can hear.
  • I accept responsibility if my anger has hurt someone.
  • I direct my anger appropriately.
  • I do not use anger to intimidate.
  • I express anger in words, not actions, unless in protection.

3. When You Feel Invisible

If you tend to feel unnoticed or unimportant, you may feel the weight of abandonment. When you’ve experienced a lack of parental presence or emotional support, this can impact your self-worth and purpose to deepen your sense of self.

Positive Affirmations:

  • I am loved.
  • I am unique.
  • I am significant.
  • I am seen by the people who see me (name them out loud).
  • I am making a difference in the lives of my loved ones.

4. When Past Trauma Is Haunting You

Lingering memories of past trauma—whether from an accident, relationship, or significant life event—often make you feel vulnerable. Recite positive affirmations to help ease painful memories and encourage mental wellness.

Positive Affirmations:

  • I am safe within this moment.
  • I have everything I need at this moment.
  • I release trauma, turmoil, and grief.
  • Asking for help is a sign of strength.

5. When You Feel Inferior

“Comparison is the thief of joy.” A truer statement has never been said about what you can stop doing right now to feel happier. When you find yourself comparing your achievements or appearance with others, it’s easy to feel inferior.

It’s a common struggle, but positive affirmations can help redirect your focus to accept and love who you are right now.

Positive Affirmations:

  • I will refrain from comparing myself to others.
  • I am a strong, independent person.
  • I will be my best, not someone else’s best.
  • I work hard.

6. When you Feel Shame

Studies show that shame and regret can be some of the most powerful forces when it comes to your emotional health. While excessive shame can be harmful to your mental health, a moderate amount may motivate you toward more positive behavioral change.

Letting go of negative self-talk is possible with the intentional practice of self-compassionate affirmations.

Positive Affirmations:

  • Each day I feel more at peace with my past mistakes.
  • I work to learn the lessons of my past.
  • I can and will let go of any shame that haunts me.
  • That was then; this is now.

7. When You Feel Overly Responsible

Feeling overly responsible for other people’s happiness can lead to imbalanced relationships, emotional exhaustion, resentment, and long‐term stress.

Giving yourself as much compassion as you give others is essential in living a happier and more purposeful life. You can start by establishing boundaries and reminding yourself that you’re not alone in caring for others.

Positive Affirmations:

  • Loving others as myself means taking care of myself so I can love others.
  • I help others as long as it helps them become independent.
  • It’s better to give than to receive—if it doesn’t create dependency.
  • I share the load, so I don’t become overburdened.
  • I do what I can and trust others to God’s care.

8. When You’re Feeling Overwhelmed

Thoughts of aging, mortality, and the fleeting nature of life can feel overwhelming at times. This has been especially prevalent in the past decade. A 2024 study in Frontiers in Psychology shows that things like global political discourse, natural disasters, and a pandemic on top of personal life events can compound certain anxieties.

Positive affirmations encourage living fully and without fear by learning to cope by grounding yourself in the present moment.

Positive Affirmations:

  • I will live a life that matters.
  • I live fully and fearlessly.
  • I am present in all I do.
  • If something is meaningful, I pursue it; if not, I let it go.

9. When You’re Grieving   

Loss can leave a lasting impact, but healing is possible. Grief is often the last act of love you can express in the wake of losing of a loved one. Findings in a 2024 study suggest that affirmations can help you grieve and offer hope through the healing process.

It’s not about moving on from your loved one—it’s about having the courage to move forward with their memory.

Positive Affirmations:

  • I feel my feelings and cry when needed.
  • I choose to heal and move forward.
  • I hold on to love and let go of grief.
  • Seeking help is a sign of strength.
  • Even though I’ll never be the same, it’s OK to be someone new.

10. When You’re Feeling Hopeless

If you’re feeling hopeless, please know that you don’t have to feel alone. Some situations can feel impossible to change which, over time, can lead to a mindset of learned helplessness.

Start saying these phrases to help reframe your thoughts and renew hope for a better future that you control.

Positive Affirmations:

  • I am worth it.
  • I can ask for help when I need it.
  • I have hope for the future.
  • Today is going to be a great day.

THE POWER OF AFFIRMATIONS

By practicing these affirmations, you’re empowering yourself with simple yet powerful tools. When repeated regularly, it can help shift your brain chemistry and boost your mood to break patterns of negativity and embrace positive thinking.

We Are Here For You

Anxiety, depression, stress, and other mental health conditions can’t wait. At Amen Clinics, we’re here for you. We offer in-clinic brain scanning and appointments, as well as mental telehealth, clinical evaluations, and therapy for adults, teens, children, and couples. Find out more by speaking to a specialist today at 888-288-9834 or visit our contact page here.

Cascio, Christopher N et al. “Self-affirmation activates brain systems associated with self-related processing and reward and is reinforced by future orientation.” Social cognitive and affective neuroscience vol. 11,4 (2016): 621-9. doi:10.1093/scan/nsv136

Budiarto Y, Helmi AF. Shame and Self-Esteem: A Meta-Analysis. Eur J Psychol. 2021 May 31;17(2):131-145. doi: 10.5964/ejop.2115. PMID: 35136434; PMCID: PMC8768475

Gérain P, Zech E. Do informal caregivers experience more burnout? A meta-analytic study. Psychol Health Med. 2021 Feb;26(2):145-161. doi: 10.1080/13548506.2020.1803372. Epub 2020 Aug 20. PMID: 32816530

Gabriela, M., Laurențiu, M., & Camelia-Iulia-Maria, V. (2024). The relationship between critical life events, psycho-emotional health and life satisfaction among youths: Coping mechanisms and emotional regulation. Frontiers in Psychology, 14. https://doi.org/10.3389/fpsyg.2023.1288774

Baiu, B. (2024). Self-affirmation Shortens the Grieving Process after Romantic Abandonment and can Increase Self-esteem. International Journal of Indian Psychology, 12(4), 577-589. DIP:18.01.052.20241204, DOI:10.25215/1204.052

Nickerson, C. (2024, May 2). Learned Helplessness. Simply Psychology. www.simplypsychology.org/learned-helplessness.html

DeAngelis, T. (2019, February). The legacy of trauma. APA Monitor, 50(2). www.apa.org/monitor/2019/02/legacy-trauma 

Yehuda R, Lehrner A. Intergenerational transmission of trauma effects: putative role of epigenetic mechanisms. World Psychiatry. 2018 Oct;17(3):243-257. doi: 10.1002/wps.20568. PMID: 30192087; PMCID: PMC6127768.

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Functional Psychiatry: A Better Approach to Mental Health Care

Functional Psychiatry A Better Approach to Mental Health Care
Functional medicine psychiatry addresses patients’ complexities by taking into account the many elements of their life, health, and environment. This approach reaches far beyond just

Imagine you cut your finger and your body wasn’t able to naturally heal itself. Would applying a bandage over the cut truly help? It might put a short-term protective cover on top of the problem, but the cut would remain—and might even worsen over time.

This analogy can be used to illustrate the differences between traditional and functional psychiatry, also called integrative psychiatry. Traditional psychiatry follows the principles of traditional Western medicine, where the focus is typically placed on treating symptoms alone.

But in functional psychiatry, as in modern integrative psychiatry, symptoms are just part of the equation. What’s more important is determining—and then treating—the root causes of the problem, which creates a better chance of successful mental health outcomes.

THE FUNCTIONAL PSYCHIATRY APPROACH TO MENTAL HEALTH CARE

When a patient describes having depression or anxiety, for example, a traditional psychiatrist may ask about the symptoms they’re experiencing in order to arrive at a diagnosis. Many mental health professionals then prescribe antidepressants as the first line of defense.

In research collected from 2015-2018, the Centers for Disease Control (CDC) reported that 13.2% of adults had taken antidepressants in the last 30 days. And, according to a study published in Pediatrics in 2024, prescriptions for antidepressants skyrocketed among young people through the pandemic. These grew by more than 66% between 2016-2022.

What these stats don’t show are the large numbers of people reporting treatment-resistant depression, which means that antidepressants aren’t helping. At the same time, numerous modern-day realities, from the Standard American Diet to increasing use of electronic devices, continue to wreak havoc on Americans’ mental health.

Clearly, medical experts must offer better solutions to promote their patients’ optimal mental well-being. Simply prescribing medications can be the equivalent of putting a bandage on a wound without actually healing it. The human body is a complex organism, living in complex environments and coping with various stressors (and stress responses) that are unique to each person.

Functional medicine psychiatry addresses patients’ complexities by taking into account the many elements of their life, health, and environment. This approach reaches far beyond just the symptoms and into the underlying root causes to outline a targeted mental health treatment plan.

At Amen Clinics, it’s an approach called the Four Circles of Mental Health: biological, psychological, social, and spiritual.

When the entire individual is examined—not just their symptoms—there’s a better chance of addressing the problem at the root, leading to more effective treatment. In fact, functional psychiatry practitioners know that many mental health issues, such as depression and anxiety, can be improved with natural remedies and may not require medication at all.

ADDRESSING UNDERLYING FACTORS

Antidepressants are not a cure-all for patients because mental health issues like anxiety and depression are not single disorders with a single cause. For example, brain SPECT studies at Amen Clinics have led to the discovery of seven types of anxiety and depression, seven types of attention deficit disorder (ADD), six types of addiction, and five types of overeaters.

As neuroimaging studies show, mental health is really brain health. SPECT scans are crucial aids in the functional psychiatry approach, because they show blood flow and activity in the brain. They are instrumental in finding underlying mental health destroyers that can go overlooked in traditional psychiatry, such as:

  • Head trauma/brain injury/concussion
  • Environmental toxin exposure
  • Brain inflammation
  • Infections such as Lyme disease

Other factors can also contribute to mental health issues, including genetics, biological causes, long-term stress, sleep issues, poor diet, lack of physical activity, and social isolation/loneliness. Evaluating all of these helps paint a full picture of each patient.

Therefore, in functional medicine psychiatry, a person diagnosed with a mental health condition wouldn’t simply be prescribed psychiatric medication and sent on their way. Instead, they would be assessed in these four areas of their health and well-being, enabling a holistic approach to healing and recovery:

  1. Biological health examines factors like hormonal imbalances, previous brain injury, chronic health conditions, thyroid activity, gut health, inflammation, environmental toxin exposure, and infections. Evaluation can include diagnostic lab tests and brain scans.

Incorporating basic practices like eating a healthy diet (including supplements as needed), getting enough physical activity, proper sleep hygiene, and maintaining low stress levels is also crucial. These help support the physical body, boost mood, and promote overall mental health.

  1. Psychological well-being allows for better resilience to the stressors that inevitably occur in life. When habits like automatic negative thoughts become second nature, mental health suffers. Steps like cognitive behavioral therapy (CBT) and dialectical behavior therapy (DBT) can help change these damaging habits.

In addition, factors like trauma, adverse childhood experiences (ACEs), and post-traumatic stress disorder (PTSD) can sabotage mental health. Processing these with a trusted professional, using techniques such as EMDR therapy, helps foster psychological well-being.

  1. Social connections refer to a person’s family, friends, and community. These can include mental health professionals, support groups, or mental health organizations. This is a crucial aspect of mental health, as a long-term Harvard study found that relationships are the biggest predictors of humans’ health and longevity.

Unfortunately, many people today suffer from isolation—America’s latest epidemic, the U.S. Surgeon General warned in 2023—which erodes mental health. Taking time to create and maintain stronger interpersonal bonds can be a necessary step in recovery.

  1. Spiritual wellness relates to having a sense of purpose in life and believing in something bigger than oneself. This type of well-being can be improved by assessing values, practicing mindfulness, spending time in nature, and helping others.

Meditation, prayer, listing daily gratitudes, yoga, chanting, and organized religion are additional ways people strengthen their spiritual sides. Spirituality has also been associated with increased longevity in numerous studies.

Assessing all four of these aspects of wellness helps create a comprehensive, customized mental health treatment plan that considers all areas of a person’s life. Ultimately, this functional medicine approach acknowledges that many factors influence mental health. Addressing symptoms at the root level means we must take all of them into account.

THE BENEFITS OF FUNCTIONAL MEDICINE

According to The Institute for Functional Medicine (IFM), functional medicine endeavors to reduce healthcare burdens on our nation by promoting better health outcomes and saving on costs. After all, unlike prescription medication, tactics like meditation, peer support groups, and daily exercise can be completely free for both patients and the healthcare system.

In addition, treatments tend to be more successful when they take the full human being into account, not only their symptoms. Just as mental health issues do not occur for a single reason, they don’t manifest in the same ways for every patient. And what helps one person may be ineffective or even harmful for another.

People who struggle with mental health conditions, from bipolar disorder and borderline personality disorder to schizophrenia and attention deficit hyperactivity disorder (ADHD), must be seen as more than their symptoms. They also deserve to escape the stigma that still surrounds mental health diagnosis and treatment.

Fortunately, functional medicine helps mental health professionals address each patient compassionately and individually. Practitioners and patients alike obtain a holistic view of their unique concerns and symptoms—and the many factors behind them. When it comes to mental health, diagnosis and treatment should never be one-size-fits-all.

We Are Here For You

Anxiety, depression, stress, and other mental health conditions can’t wait. At Amen Clinics, we’re here for you. We offer in-clinic brain scanning and appointments, as well as mental telehealth, clinical evaluations, and therapy for adults, teens, children, and couples. Find out more by speaking to a specialist today at 888-288-9834 or visit our contact page here.

CDC, Antidepressant Use Among Adults: United States, 2015-2018, NCHS Data Brief No. 377, September 2020, Debra J. Brody, M.P.H., and Qiuping Gu, M.D., Ph.D. https://www.cdc.gov/nchs/products/databriefs/db377.htm

Kao-Ping Chua, Anna Volerman, Jason Zhang, Joanna Hua, Rena M. Conti; Antidepressant Dispensing to US Adolescents and Young Adults: 2016–2022. Pediatrics March 2024; 153 (3): e2023064245. 10.1542/peds.2023-064245

Good Genes Are Nice, but Joy Is Better by Liz Mineo. The Harvard Gazette. https://news.harvard.edu/gazette/story/2017/04/over-nearly-80-years-harvard-study-has-been-showing-how-to-live-a-healthy-and-happy-life/

Dominguez LJ, Veronese N, Barbagallo M. The link between spirituality and longevity. Aging Clin Exp Res. 2024 Feb 11;36(1):32. doi: 10.1007/s40520-023-02684-5. PMID: 38341843; PMCID: PMC10859326.

The Institute for Functional Medicine, https://www.ifm.org/functional-medicine/

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Psychology of Scare: Why Do People Like Getting Scared?

The rush of feel-good chemicals triggered in the fight-or-flight response—dopamine, endorphins, and oxytocin—leads to improved feelings of well-being after the threat has passed.

Halloween haunted houses, true-crime television, roller coasters, horror movies—these hair-raisers aren’t everyone’s idea of a great time. But such fear-inducing thrills have become compelling attractions for many Americans.

Perhaps it seems counterintuitive that anyone would want to experience fear. Though it has served a crucial evolutionary purpose in keeping humans safe from harm, it’s generally considered a negative emotion.

Yet kids and adults alike enjoy subjecting themselves to the scares that accompany events like Halloween or extreme sports like rock climbing. Some say being afraid even makes them feel more alive.

What does fear actually do to our brains and bodies—and why do we intentionally seek out frightening experiences? Let’s take a look at some of the psychological, physiological, and emotional effects of fear, including their benefits and potential drawbacks.

WHAT’S BEHIND THE THRILL OF FEAR?

In a 2020 study called “Playing With Fear: A Field Study in Recreational Horror,” authors examined enjoyable fear—the kind that people seek out through stimuli like haunted houses. They listed previous research findings that help explain the appeal of these activities, such as:

  • Confronting repressed desires
  • An opportunity to act out expected gender roles
  • The enjoyment of unpleasant experiences while feeling safe, known as hedonic reversal

While these explanations may resonate with fear-seekers, there are more reasons why being exposed to a sense of danger might create feelings of pleasure. Here are a few of the most notable.

  1. Physiological changes

When you’re afraid, your brain and body go through a variety of changes, including:

  • Increased dopamine release in the brain
  • Activation of the amygdala, an almond-shaped structure within the brain’s temporal lobes that senses fear
  • Release of stress hormones, including cortisol and adrenaline
  • Increased breathing, heart rate, and blood pressure
  • Increased blood flow to muscles and increased muscle strength (affecting the muscles needed for a fight response)

At the same time, peripheral vision narrows in order to more fully focus on the threat, an effect known as tunnel vision. You might start sweating or break out in goosebumps. All of these changes are part of the fight-or-flight response and have helped human beings survive throughout evolution.

But the rush of feel-good chemicals triggered in this response—dopamine, endorphins, and oxytocin—leads to improved feelings of well-being after the threat has passed. This explains why you may feel euphoria or start laughing in the wake of a scary event.

  1. Strengthened ability to confront fears

When fear is produced in a controlled environment, it can be beneficial to those who endure it and emerge safely afterward. The ability to successfully confront and then overcome fear can serve to boost inner strength and resilience, equipping people for subsequent real-life situations that are threatening.

Scholars have suggested that feeling fear, “when tolerable and in a safe and controlled environment, such as through viewing horror movies, could benefit individuals by preparing and practicing specific skills like emotion regulation and distress tolerance.”

Indeed, a 2019 study published in the medical journal Emotion examined the aftereffects of voluntary arousing negative experiences—in this case, haunted house visits. The results found that participants reported that their affect improved, especially those who felt tired, bored, or stressed before having the scary experience.

After the event, these subjects showed less neural reactivity in the face of stress. These results suggest that controlled fear experiences could help them better cope with later stressors.

  1. Building interpersonal bonds

Fear and hardship are powerful bonding agents among humans. This drives the lifelong camaraderie built among soldiers who have faced war together, or in communities that have endured a natural disaster.

We can also witness this phenomenon in a theater full of horror movie goers (or even between a couple who visits such a movie on a date). This is a side effect of the oxytocin release mentioned above as part of the fight-or-flight response.

When people face and overcome a threat together, it tends to bring them closer. As researchers have noted, “the same biological systems that supported social bonds and reproduction enhanced the capacity to overcome fear, stress, and disease” throughout our evolution.

In other words, fear and love are inextricably linked. Our desire for safety from threats has made humans more likely to seek out each other. And our relationships have increased our perceived feelings of safety in the face of danger.

  1. Escapism and catharsis

When the demands of real life feel overwhelming, many people seek out the escapism of pastimes like movies and television. And, for some, scary tales help them more effectively forget about their own troubles.

When people watch characters on a screen face real or imaginary dangers, like in a horror movie or through dangerous sports events, they can transfer their own feelings of anxiety to an outside party. They feel comforted as a result.

In addition, people can experience catharsis through scary experiences, whether watching them on a screen or personally participating in them, such as by riding a roller coaster. Fear can elicit responses like screaming, shaking, or tingling, which can work to release unpleasant emotions.

Not surprisingly, studies have found that those with a penchant for sensation seeking are most likely to enjoy entertainment options that include fright and violence. Other factors, such as empathy, tendency toward aggression, and gender, can also affect subjects’ enjoyment levels.

WHEN FEAR GOES TOO FAR

Although watching a horror movie, entering a haunted house, or riding a roller coaster can be fun and safe ways to generate fear, there can be negative effects, too.

For example, young children may not yet have the capacity to distinguish imaginary threats from real ones. They can experience stress, nightmares, and even panic attacks after partaking in fearful experiences like watching scary movies. Lasting negative effects can happen to adults, too, like increased anxiety after the controlled-fear event concludes.

Adults who have experienced severe traumas or who have post-traumatic stress disorder (PTSD) may prefer to avoid consuming frightening content. When something in a film recreates the viewer’s traumatic event, such as sexual assault or war, it can trigger unwanted consequences like flashbacks.

However, for reasons explained in #2 above, others believe that facing the things that scare us most can be helpful and therapeutic, if done properly. This is the rationale behind exposure therapy, used to treat phobias.

There is also a common effect among those who may be labeled “adrenaline junkies,” wherein—just like with drug users—they may need to create more intense adrenaline rushes over time. Loving an adrenaline rush is commonly seen in people with attention deficit hyperactivity disorder (ADHD), also called attention deficit disorder (ADD).

In some cases, they can develop a tolerance to lower-grade thrills and seek out increasingly scarier experiences to get the same effect, which can eventually put them in real danger.

Ultimately, deciding whether to partake in scary events, hobbies, or entertainment is a personal decision that should be made carefully. Each person will have a different capacity to process their fears. But for those who love a frightful thrill, subjecting themselves to scares can be a fundamental human experience that offers surprising psychological benefits.

We Are Here For You

Anxiety, depression, stress, and other mental health conditions can’t wait. At Amen Clinics, we’re here for you. We offer in-clinic brain scanning and appointments, as well as mental telehealth, clinical evaluations, and therapy for adults, teens, children, and couples. Find out more by speaking to a specialist today at 888-288-9834 or visit our contact page here.

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Helena Carreira, Rachael Williams, Martin Müller, Rhea Harewood, Susannah Stanway, Krishnan Bhaskaran, Associations Between Breast Cancer Survivorship and Adverse Mental Health Outcomes: A Systematic Review, JNCI: Journal of the National Cancer Institute, Volume 110, Issue 12, December 2018, Pages 1311–1327, https://doi.org/10.1093/jnci/djy177

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National Cancer Institute, Emotions and Cancer, https://www.cancer.gov/about-cancer/coping/feelings

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Understanding Depression and Memory Loss Causes and Solutions

Recover From Memory Loss
More than half of the people who develop depression experience cognitive changes, such as memory problems and brain fog.

Anyone who has ever suffered from depression knows how impairing the mood symptoms can be. The pervasive sadness or irritability along with trouble sleeping, feeling hopeless, fatigued, and empty makes the world seem much darker than it is.

As if these aren’t difficult enough, clinical depression can also affect memory and hurt the cognitive functioning of your brain (and not just in older adults) although this isn’t mentioned as much as the other symptoms are.

More than half of depressed individuals also experience memory problems and brain fog. And when memory impairment arises, some people may even worry they are developing Alzheimer’s disease.

Although it may be difficult to discern these mental health issues from other depression symptoms in the midst of an episode, such changes in cognitive function can nonetheless disrupt a person’s thinking skills and ability to remember things, even after the other depression symptoms have lifted.

More than half of the people who develop depression experience cognitive changes, such as memory problems and brain fog. Share on X

HOW DEPRESSION IMPACTS BRAIN FUNCTION AND MEMORY

Like most mental health conditions, depression is complex and isn’t a simple or single disorder. In fact, symptoms can be caused by many different factors, including changes in the brain’s structure and function. Therefore, treating memory loss or other cognitive impairments that so often accompany major depressive disorder can be a challenge.

Clinically important research on depression, published in the medical journal Neuroimage: Clinical, utilized magnetic resonance imaging (MRI) and found decreased grey matter (atrophy) in the brain.

Atrophy was especially noted in two brain regions:

  • Prefrontal cortex (PFC)

  • Anterior cingulate gyrus (ACG)

These areas of the brain are involved with paying attention, planning, decision-making, and judgment, along with other important aspects of cognitive function.

Similarly, in a study in the Journal of Affective Disorders, researchers observed decreased activity (low blood flow) in the PFC and ACG as well as other areas. Other brain regions included the left temporal lobe, a part of the brain that is critical for memory and emotional processing.

This suggests that the depression-memory loss connection is very real!

CAUSES FOR THE DEPRESSION-MEMORY LOSS CONNECTION

Although the specific underlying reasons for findings like these are still being researched, science does know there are several potential causes for the link between depression and memory loss.

  • Decreased synaptic connections: One is that during depressive episodes there often is a decrease in synaptic connections in the brain. This means that the communication between brain cells is disrupted and affects memory function, which can explain poor recollection or memory retrieval.

  • Brain chemical abnormalities: Abnormalities in neurotransmitters—such as decreased levels of serotonin and dopamine—and other brain chemicals can lead to a wide range of depressive symptoms.

    They can also contribute to symptoms related to cognition and memory troubles, as well as a tendency to focus on negative events. Thus, when people seek treatment for depression, medications, such as selective serotonin reuptake inhibitors (SSRIs) might be recommended to help balance brain chemistry.

Despite how concerning the abnormalities in brain function might sound, most people who struggle with depression and its persistent sad mood will find that the right mental health treatment options can help.

Positive lifestyle strategies and other depression treatments can not only boost mood and energy but also help with memory loss and clear up that annoying brain fog that disrupts normal executive function.

5 NEUROSCIENCE TIPS TO REVERSE MEMORY ISSUES DUE TO DEPRESSION

Taking steps to heal from depression and memory loss associated with it can improve how you feel as well as how your brain works. It requires doing things that support your brain function and avoiding behaviors that are harmful to it.

The following neuroscience-based lifestyle strategies can help you get back on your game again.

1. Begin (or resume) a regular exercise regimen.

Depression affects motivation, so when feeling really down, getting started might be hard at first. But, once you take that first step—even if it’s going for a walk down the street—you’ll notice it makes you feel a little better, which will motivate you to do it more often.

This happens because exercise increases blood flow in the brain and causes the release of neurotransmitters, like serotonin and dopamine, that help people focus more on positive events rather than negative cognitions (thoughts).

Research published in CNS Neuroscience & Therapeutics found that strength training, aerobic activity, and mind-body exercise, such as yoga, can reduce depressive symptoms and induce neuroplasticity—the brain’s ability to repair itself.

Furthermore, getting regular exercise is critical for reducing the risk of developing long-term cognitive impairment or Alzheimer’s disease.

2. Give meditation a try.

If you’ve never meditated before, when you do experience it, you will likely be pleased by the way it helps you feel more centered and grounded, as well as how it can improve brain function.

A 2019 study that analyzed the benefits of a daily 13-minute guided meditation over the course of eight weeks resulted in a better memory, mood, and focus, among other gains for the participants.

3. Consider transcranial magnetic stimulation (TMS).

This non-invasive technology, which is FDA approved for the treatment of depression symptoms, uses a powerful magnet to stimulate blood flow in the brain.

In addition to it helping reduce depressive symptoms, a meta-analysis (review of multiple studies) published in Psychological Medicine found that TMS also improved working memory. This is the short-term memory that holds small bits of information needed from moment to moment while working on a task.

During a depressive episode, short-term memory is often compromised, which can cause difficulty concentrating making it hard to get things accomplished. With TMS, symptoms of depression and memory loss can be improved.

4. Switch to an anti-inflammatory diet.

Although you aren’t likely to physically feel inflammation in your brain, it can be a contributing factor to depression and memory loss and can cause brain fog.

Sugar and other high-glycemic foods as well as ones that are processed with hydrogenated oils promote inflammation and can exacerbate symptoms.

Therefore, it’s important to opt instead for foods that support the cognitive function of your brain, such as those found in a Mediterranean diet—tomatoes, leafy greens, berries, legumes, nuts, olive oil, and cold-water fish like salmon.

Nutritional supplements like omega-3 fatty acids and curcumins also have anti-inflammatory properties.

5. Give your brain a workout.

Just like we need to exercise our muscles to stay strong, we also need to engage in brain workouts, especially after depression-related memory problems have gotten in your way.

There are some very accessible (and often free) tools that affect memory and other residual cognitive issues in a helpful way and can easily be incorporated into your day. For example:

  • Tackle word search puzzles, Sudoku, Wordle, and crossword puzzles.

  • Try online brain games that require concentration, recall, and speed.

  • Learn new words from the dictionary (and practice using them).

  • Memorize the alphabet backward.

As your memory issues decrease and you’re able to think more clearly, boost your executive function even more with challenges like these:

  • Take a class on a new subject or hobby that interests you.

  • Brush up on the foreign language you studied in high school.

  • Learn to play a musical instrument, or learn a different one if you’re already skilled with a particular instrument.

To further enhance your cognitive function as you incorporate these treatment options to recover from depression, it is vital to get at least seven hours of sleep each night, increase your social connectedness, and avoid alcohol and recreational drugs like marijuana because they adversely affect mood and cognition functions, including memory problems.

OVERCOME DEPRESSION-RELATED MEMORY LOSS WITH DAILY PRACTICE

As you have learned here, depression and memory treatment options go beyond antidepressant medications like selective serotonin reuptake inhibitors.

By practicing healthy lifestyle choices every day, you increase your capacity to heal from memory issues related to depression. This means you can get back to doing the things that you bring joy and fulfillment—and create positive memories to cherish in the future.

We Are Here For You

Anxiety, depression, stress, and other mental health conditions can’t wait. At Amen Clinics, we’re here for you. We offer in-clinic brain scanning and appointments, as well as mental telehealth, clinical evaluations, and therapy for adults, teens, children, and couples. Find out more by speaking to a specialist today at 888-288-9834 or visit our contact page here.

Remes O, et al. Generalised anxiety disorder and excess cancer deaths: findings from a large, longitudinal population study. The Lancet, Volume 388, Special IssueS100, November 2016. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)32336-4/fulltext

American Cancer Society, 2024—First Year the US Expects More than 2M New Cases of Cancer, January 17, 2024, https://www.cancer.org/research/acs-research-news/facts-and-figures-2024.html

Singer, J. Das-Munshi, E. Brähler, Prevalence of mental health conditions in cancer patients in acute care—a meta-analysis, Annals of Oncology, Volume 21, Issue 5, 2010, Pages 925-930, ISSN 0923-7534, https://doi.org/10.1093/annonc/mdp515. https://www.sciencedirect.com/science/article/pii/S0923753419392221

Purushotham, S. Bains, G. Lewison, G. Szmukler, R. Sullivan, Cancer and mental health—a clinical and research unmet need, Annals of Oncology, Volume 24, Issue 9, 2013, Pages 2274-2278, ISSN 0923-7534, https://doi.org/10.1093/annonc/mdt214. https://www.sciencedirect.com/science/article/pii/S0923753419369467

Helena Carreira, Rachael Williams, Martin Müller, Rhea Harewood, Susannah Stanway, Krishnan Bhaskaran, Associations Between Breast Cancer Survivorship and Adverse Mental Health Outcomes: A Systematic Review, JNCI: Journal of the National Cancer Institute, Volume 110, Issue 12, December 2018, Pages 1311–1327, https://doi.org/10.1093/jnci/djy177

Caruso R, Breitbart W. Mental health care in oncology. Contemporary perspective on the psychosocial burden of cancer and evidence-based interventions. Epidemiol Psychiatr Sci. 2020 Jan 9;29:e86. doi: 10.1017/S2045796019000866. PMID: 31915100; PMCID: PMC7214708.

Gupta A, Hurley C, Mangal R, Daniel A, Ganti L. Cancer caregivers are primarily motivated by love and sense of duty. Health Psychology Research. 2024;12. doi:10.52965/001c.92643

American Cancer Society, Depression, https://www.cancer.org/cancer/managing-cancer/side-effects/emotional-mood-changes/depression.html

American Cancer Society, Anxiety, https://www.cancer.org/cancer/managing-cancer/side-effects/emotional-mood-changes/anxiety.html

National Cancer Institute, Emotions and Cancer, https://www.cancer.gov/about-cancer/coping/feelings

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9 Ways to Ruin Your Relationship

two hands holding
Everybody wants to know the secrets to a strong relationship and a happy marriage, but it can be just as important to know what leads

Everybody wants to know the secrets to a strong relationship and a happy marriage, but it can be just as important to know what leads to marital conflict. By understanding what you—or your significant other—are doing to mess things up, you can learn how to turn things around to create healthy relationships.

In this blog, you’ll discover some of the most common relationship killers and how they’re often linked to unhealthy brain activity.

If you want to learn additional things people do to sabotage relationships as well as simple brain health strategies to overcome these issues and strengthen your marriage, tune in to the Change Your Brain Every Day podcast, hosted by Dr. Daniel Amen and his wife Tana Amen. Their two-part series on relationships is available wherever you get your favorite podcasts.

9 WAYS TO RUIN A RELATIONSHIP

  1. Saying everything that pops into your head

Anyone who is married knows that it’s best to keep some thoughts to yourself. But some people can’t help blurting out the rude thoughts that pop into their head, and it leads to relationship trouble.

This may be related to lower-than-normal activity in the brain’s frontal lobes. Over 250,000 brain SPECT scans on over 100,000 patients at Amen Clinics show that low activity in the prefrontal cortex is commonly seen in people with attention deficit hyperactivity disorder (ADHD), also known as attention deficit disorder (ADD), or a history of head injury.

Other neuroimaging research confirms the link between reduced brain activity in this region and ADHD. Decreased activity in the PFC is linked to impulsivity, which can make you blurt out things that are hurtful to the one you love.

  1. Playing “let’s have a problem”

Have you ever noticed how some people like to get their loved ones riled up? It’s as if they like the “excitement” that comes from starting arguments or “poking the bear.” But this isn’t helpful for your marriage.

This tendency is commonly seen in people with ADD/ADHD, who have low activity in the frontal lobes. It serves as a way for them to stimulate brain activity by boosting blood flow in the brain. Unfortunately, this innate need to stimulate the brain leads to trouble in relationships.

  1. Holding on to past hurts

When you can’t forgive your significant other, or you can’t get beyond arguments from the past, it can be a sign of an overactive anterior cingulate gyrus (ACG). This area of the brain acts like a gear shifter.

When your ACG works too hard, you tend to get stuck on old hurts or hold grudges. In addition, if you don’t take responsibility for your own role in the past problems and you blame your spouse for everything that went wrong, you’re headed for more problems.

  1. Not focusing on what you want

What is your ultimate goal in your marriage? Is it to prove that you’re right all the time? Or is it to have the best relationship possible?

If you don’t know what your overarching goal is, you won’t be able to focus on the behaviors that will help you achieve it. And you’ll be more likely to do things that can sabotage it—rather than make it better.

  1. Not getting enough zzzz’s

When you skimp on sleep or suffer from chronic insomnia, your brain can’t function optimally, and this can affect your mood, decision-making, and memory.

If sleep issues contribute to being in a rotten mood, forgetting your anniversary, or deciding to go out drinking with friends instead of being with your spouse their birthday, it’s going to lead to big issues.

  1. Hanging with the wrong crowd

If you surround yourself with negative people who constantly complain about what’s wrong with their marriage, guess what? You’ll probably start complaining too.

When you focus on the negative, you train your brain to look for what’s wrong, rather than noticing what’s right. What might make this even worse is that a 2020 research study found that repetitive negative thinking may increase the risk for Alzheimer’s disease.

  1. Having an extramarital affair…with your phone!

Staring at your phone so you can scroll through your social media feed while you’re having lunch with your spouse is a relationship killer. The inability to resist the lure of your phone—AKA “phubbing” (phone snubbing)—makes the other person feel ignored and not worthy of your attention. Is that what you really want?

Plus, it can also be a sign that you’ve got attentional issues or even addiction problems. A study published in the International Journal of Environmental Research and Public Health found that excessive use of social networking sites can lead to some of the same symptoms that are commonly seen with substance use addictions.

  1. Being addicted to alcohol, drugs, or anything else

If you’re drinking too much alcohol, smoking marijuana, or watching pornography on an endless loop, it is likely interfering with being present in your marriage.

Addictive behavior alters the way the brain functions, according to a growing body of scientific evidence. Unhealthy, out-of-control habits can damage brain function and lead to more bad decisions and destructive behaviors.

  1. Ignoring mental health conditions and brain health issues

The brain-imaging work at Amen Clinics using SPECT scans shows that mental health issues—such as clinical depression, anxiety disorders, obsessive-compulsive disorder (OCD), bipolar disorder, and post-traumatic stress disorder (PTSD)—are really brain health issues.

These mental health conditions are all rooted in brain function and when left undiagnosed, untreated, or improperly treated, they can destroy a marriage.

For example, when you’re depressed, it’s difficult to think of anyone but yourself, and that can create a disconnect between the two of you.

When a spouse doesn’t understand their partner has a brain health problem, bad behavior can be taken personally and make them feel like their significant other doesn’t love them, is being mean on purpose, or is quite simply, a jerk.

Unless you treat the underlying brain health problems, it can be challenging to have a healthy relationship. It can also get in the way of making progress in couples therapy or marital therapy. Healing the root causes of the problem is the key to a better partnership.

HOW TO BUILD A HEALTHIER RELATIONSHIP

By becoming more aware of how your decisions and behavior many be dismantling the health of your relationship, you can start making the positive changes necessary to rebuild the trust and love that brought the two of you together in the first place.

To learn simple strategies to fortify your relationship, don’t miss Dr. Amen and Tana’s two-part series on relationships on the Change Your Brain Every Day podcast, available wherever you get your favorite podcasts.

We Are Here For You

Marital conflict and relationship issues, anxiety, depression, ADD/ADHD, addictions, and other mental health issues can’t wait. At Amen Clinics, we’re here for you. We offer in-clinic brain scanning and appointments, as well as mental telehealth, clinical evaluations, and therapy for adults, teens, children, and couples. Find out more by speaking to a specialist today at 888-288-9834 or visit our contact page here.

Arnsten, Amy F T. “The Emerging Neurobiology of Attention Deficit Hyperactivity Disorder: The Key Role of the Prefrontal Association Cortex.” The Journal of pediatrics vol. 154,5 (2009): I-S43. doi:10.1016/j.jpeds.2009.01.018

Marchant, Natalie L et al. “Repetitive negative thinking is associated with amyloid, tau, and cognitive decline.” Alzheimer’s & dementia : the journal of the Alzheimer’s Association vol. 16,7 (2020): 1054-1064. doi:10.1002/alz.12116

Kuss, Daria J, and Mark D Griffiths. “Social Networking Sites and Addiction: Ten Lessons Learned.” International journal of environmental research and public health vol. 14,3 311. 17 Mar. 2017, doi:10.3390/ijerph14030311

Substance Abuse and Mental Health Services Administration (US); Office of the Surgeon General (US). Washington (DC): US Department of Health and Human Services; 2016 Nov. acing Addiction in America: The Surgeon General’s Report on Alcohol, Drugs, and Health [Internet], Chapter 2: The Neurobiology of Substance Use, Misuse, and Addiction. https://www.ncbi.nlm.nih.gov/books/NBK424849/

 

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Cancer and Mental Health: Everything You Need to Know

People with pre-existing mental health conditions may be more prone to anxiety or depression after being diagnosed with cancer.

Few people in the United States have not been touched by cancer—whether a loved one has faced the illness, or you’ve been personally diagnosed. The American Cancer Society reports that while cancer-related death risk has declined in the last 30 years, incidents of cancer are increasing.

In fact, 2024 is projected to be the first year in which U.S. cancer cases will surpass 2 million, equating to nearly 5,000 diagnoses daily. Deaths, meanwhile, are expected to reach more than 611,000, or 1,600 daily. Those numbers make clear that a multitude of people are living with cancer, including active cases and those in remission.

However, physically surviving with, through, and beyond cancer is only part of the battle. As with any potentially life-threatening illness, cancer can wreak havoc on your mental health and emotional stability. Being a caretaker for a loved one with cancer can also cause you to struggle.

In this blog, we’ll explore the link between cancer and mental health, providing insights and strategies to help you stay mentally strong while navigating a cancer diagnosis.

THE LINKS BETWEEN CANCER AND MENTAL HEALTH

People with pre-existing mental health conditions may be more prone to experiencing symptoms like anxiety and depression after being diagnosed with cancer. Conversely, mental disorders can negatively impact a cancer patient’s health outcomes.

For example, a 2016 study in the Lancet found that men who were diagnosed with generalized anxiety disorder had more than double the risk of cancer mortality.

Cancer and mental health conditions often overlap. In 2010, researchers performed a meta-analysis of eight studies and found that, of 1,448 cancer patients assessed, 456 were diagnosed with a mental health disorder. Rates in different populations varied from 23-53%, adding up to an overall estimate of 32% prevalence.

Others have noted a lack of research on the links between cancer and mental health. A 2013 study found a total of 1,463 research papers on this topic over a 10-year period. While that may sound like a significant number, it represents only 0.26% of cancer research and 0.51% of mental health research over that time frame.

Evaluating these studies, they researchers reported that:

  • 80% of the studies were concerned with the effects of cancer on mental health, rather than the reverse
  • 5% looked at post-traumatic stress disorder (PTSD) suffered by patients’ caregivers
  • The area of mental health most studied in cancer was unipolar depression

Still, various links between cancer and mental health issues have been established. In 2018, a systematic review of 60 studies found that, among 38 studies of depression, 33 observed more depression in breast cancer survivors. In 21 studies of anxiety, 17 noted more anxiety in breast cancer survivors.

These studies also showed survivors had “statistically significantly increased symptoms/frequency” of other mental health issues, such as:

  • Neurocognitive dysfunction (18 of 24 studies)
  • Sexual dysfunction (5 of 6 studies)
  • Sleep disturbance (5 of 5 studies)
  • Stress-related disorders/post-traumatic stress disorder (2 of 3 studies)
  • Suicide (2 of 2 studies)
  • Somatization, or mental health-related physical symptoms (2 of 2 studies)
  • Bipolar disorder (1 of 1 study)
  • Obsessive-compulsive disorder (OCD) (1 of 1 study)

By 2020, an editorial published in Epidemiology and Psychiatric Sciences estimated that mental health conditions affect at least 30-35% of cancer patients. These conditions can occur at any stage of the disease, and they can vary according to the cancer’s stage and type.

The editorial added that other mental health side effects—apart from diagnosable disorders—are believed to be present in another 15-20% of cancer patients. These effects can include demoralization, anxiety about health, loss of meaning, and existential distress.

The ties between cancer and mental health struggles are clearly numerous and complex. Further research will be helpful to examine these associations more closely. But it’s understandable that cancer might trigger or aggravate symptoms related to clinical depression, anxiety disorders, chronic stress, and more.

MENTAL HEALTH SIDE EFFECTS OF CANCER

According to the American Cancer Society, depression affects 1 in 4 people who have cancer or who have had cancer in the past. It can start anytime—from initial diagnosis until after treatment ends. Certain risk factors can increase its likelihood, such as social isolation, a history of abuse or trauma, and substance use disorder.

Meanwhile, since the illness creates significant uncertainty, anxiety is likely to occur in conjunction with cancer. The American Cancer Society reports that several aspects of the recovery process can contribute to anxiety, including:

  • Treatment and side effects of treatment
  • Changes in relationships
  • Navigating family, jobs, and responsibilities
  • Fear of death or confronting mortality

Specific cancer-related phobias may also develop as a result of anxiety, like fear of tests or scans (“scanxiety”) and fear of the cancer recurring.

Caregivers should also make sure to protect their mental health. Survey results published in 2024 found that they also struggle with adverse effects as a result of their role, including:

  • Grief (30.5%)
  • Mental health issues (28%)
  • Negative physical impacts (33%)
  • Financial stress (43.5%)
  • Lack of social support or lost friends (35%)

Overall, 75.6% of cancer caretakers reported a negative impact on their mental health in the survey, including anxiety (37.29%), depression (33.9%), and other conditions (4.41%). The number who face “overwhelming or high stress” was nearly quintupled from a baseline amount, from 13% to 59.5%.

Cancer patients, as well as their loved ones and caretakers, should seek help from mental health professionals when needed, especially if these disruptions interfere with their daily life. Ongoing symptoms like persistent low moods or panic attacks can benefit from proper treatment—and possibly even improve health outcomes for cancer patients.

COPING WITH CANCER-RELATED STRESS

As noted above, cancer patients and their caretakers can struggle with adverse effects that are not mental health conditions but are nonetheless stressful. The National Cancer Institute notes that a variety of troubling feelings can accompany cancer, such as overwhelm, fear, worry, anger, guilt, sadness, and loneliness.

On the other hand, positive emotions, like hope and gratitude, can help negate some of these negative feelings. Whether you have been diagnosed with cancer or are coping with a loved one’s diagnosis, it’s important to acknowledge and work through any difficult emotions that arise while maintaining an overall positive attitude.

Here are some helpful steps cancer patients and their loved ones can take to feel better throughout the process of cancer diagnosis, treatment, and its aftermath:

 

  1. Question any automatic negative thoughts (ANTs).
  2. Seek help through cancer support groups, hotlines, and websites.
  3. Obtain psychotherapy services for mental health conditions.
  4. Try to stay present and focus on what you can control.
  5. Eat a well-balanced, anti-inflammatory diet to help promote better mental health.
  6. Calm anxiety with simple meditations, breathing exercises, or positivity bias exercises.
  7. Stay active as much as possible to help improve mood—even if it’s just taking a walk.

MAINTAINING MENTAL HEALTH DURING CANCER

Cancer, like any serious illness, can turn your world upside-down—and your loved ones’ lives as well. Remaining vigilant about mental health symptoms when they appear, seeking help when necessary, and maintaining open communication and support systems will help ease this burden.

As cancer treatments advance, more and more people will be living with (and after) cancer—and enjoying an extended lifespan is a good thing. But this also means we must be more mindful and proactive about preserving our mental health in the process. Doing so may even improve the chances of remission and recovery.

We Are Here For You

Anxiety, depression, stress, and other mental health conditions can’t wait. At Amen Clinics, we’re here for you. We offer in-clinic brain scanning and appointments, as well as mental telehealth, clinical evaluations, and therapy for adults, teens, children, and couples. Find out more by speaking to a specialist today at 888-288-9834 or visit our contact page here.

Remes O, et al. Generalised anxiety disorder and excess cancer deaths: findings from a large, longitudinal population study. The Lancet, Volume 388, Special IssueS100, November 2016. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(16)32336-4/fulltext

American Cancer Society, 2024—First Year the US Expects More than 2M New Cases of Cancer, January 17, 2024, https://www.cancer.org/research/acs-research-news/facts-and-figures-2024.html

Singer, J. Das-Munshi, E. Brähler, Prevalence of mental health conditions in cancer patients in acute care—a meta-analysis, Annals of Oncology, Volume 21, Issue 5, 2010, Pages 925-930, ISSN 0923-7534, https://doi.org/10.1093/annonc/mdp515. https://www.sciencedirect.com/science/article/pii/S0923753419392221

Purushotham, S. Bains, G. Lewison, G. Szmukler, R. Sullivan, Cancer and mental health—a clinical and research unmet need, Annals of Oncology, Volume 24, Issue 9, 2013, Pages 2274-2278, ISSN 0923-7534, https://doi.org/10.1093/annonc/mdt214. https://www.sciencedirect.com/science/article/pii/S0923753419369467

Helena Carreira, Rachael Williams, Martin Müller, Rhea Harewood, Susannah Stanway, Krishnan Bhaskaran, Associations Between Breast Cancer Survivorship and Adverse Mental Health Outcomes: A Systematic Review, JNCI: Journal of the National Cancer Institute, Volume 110, Issue 12, December 2018, Pages 1311–1327, https://doi.org/10.1093/jnci/djy177

Caruso R, Breitbart W. Mental health care in oncology. Contemporary perspective on the psychosocial burden of cancer and evidence-based interventions. Epidemiol Psychiatr Sci. 2020 Jan 9;29:e86. doi: 10.1017/S2045796019000866. PMID: 31915100; PMCID: PMC7214708.

Gupta A, Hurley C, Mangal R, Daniel A, Ganti L. Cancer caregivers are primarily motivated by love and sense of duty. Health Psychology Research. 2024;12. doi:10.52965/001c.92643

American Cancer Society, Depression, https://www.cancer.org/cancer/managing-cancer/side-effects/emotional-mood-changes/depression.html

American Cancer Society, Anxiety, https://www.cancer.org/cancer/managing-cancer/side-effects/emotional-mood-changes/anxiety.html

National Cancer Institute, Emotions and Cancer, https://www.cancer.gov/about-cancer/coping/feelings

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Memory Loss: Is Your Medicine Cabinet to Blame?

Memory Loss Is Your Medicine Cabinet to Blame
A mounting body of scientific evidence shows that many commonly used prescription and over-the-counter medications are associated with memory loss.

Memory loss is one of the most feared issues we face in life. You may think genetics and aging are the only causes of memory problems. They’re not! Forgetfulness and fuzzy thinking might be linked to your medicine cabinet.

A mounting body of scientific evidence shows that many commonly used prescription and over-the-counter medications are associated with memory loss.

If you’re struggling with memory issues, be sure to investigate whether any medications you’re taking may be contributing to the problem. In this blog, we’ll explore eight of the most common types of drugs that increase forgetfulness and the risk of Alzheimer’s disease and other types of dementia.

8 MEDICATIONS LINKED TO MEMORY LOSS

  1. Anticholinergics 

A 2020 study in the journal Neurology revealed that taking a certain class of drugs called anticholinergics has been tied to problems with thinking and memory. There are about 100 types of anticholinergics, which are commonly used to treat high blood pressure, overactive bladder, motion sickness, Parkinson’s disease, and even the common cold, commonly used.

The study found that people with no pre-existing cognitive issues who are taking at least one anticholinergic medication are 47% more likely to develop cognitive impairment. The risk is even higher among people with a genetic vulnerability for Alzheimer’s disease.

  1. Anti-Anxiety Drugs

Anti-anxiety medications—such as Valium, Xanax, Ativan, and Klonopin—are benzodiazepines that can be effective for acute anxiety when used on a short-term basis. However, brain SPECT imaging studies show that “benzos” decrease blood flow to the brain, reduce cerebral activity, and can cause memory problems and confusion.

  1. Cholesterol-Lowering Drugs

About 20% of the body’s cholesterol is found in the brain, more than in any other organ. And the billions of nerve cells in the brain require essential fatty acids to communicate and function properly.

When cholesterol levels in the brain are too low, it may impair connectivity, which is important for memory and learning.

A 2018 review of existing studies on statins and memory loss have found conflicting results, but some show an association between the drugs and cognitive impairment.

  1. Antidepressants

 Some medications used to treat depression have been linked with memory problems. For example, tricyclic antidepressants are believed to cause memory loss by blocking the action of two important neurochemicals—norepinephrine and serotonin—that are involved in cognition and memory.

A 2018 review in Behavioral Neurology found that in elderly people, taking antidepressant medication—especially tricyclic or MAOI types—is significantly associated with an increased risk of dementia.

In this same study, another type of antidepressants called monoamine oxidase inhibitors (MAOIs) were also linked to a heightened risk for dementia in elderly patients.

  1. Opioid Painkillers

Narcotic pain medications block the sensation of pain by disrupting the transmission of pain signals from the central nervous system to receptors throughout the body. The chemical messengers responsible for this process are also critical to memory and cognitive function.

As a result, using narcotic painkillers can cause both short-term and long-term memory issues, particularly when these medications are used for extended periods. According to research in Pain Physician, long-term opioid use led to cognitive impairment, including working memory deficits, decreased spatial memory, and more.

  1. Sleep Aids

Sleep drugs, such as Ambien and Lunesta, may reduce critical REM sleep and are associated with morning grogginess, brain fog, and memory problems.

Using sleep medication was associated with a 48% increased risk of dementia in a 2023 study published in Journals of Gerontology.

  1. Anti-Seizure Drugs 

Some medications that are used in the treatment of seizures (epilepsy or convulsions), mood disorders, bipolar disorder, and nerve pain, may cause cognitive problems. Antiseizure medications work by slowing down abnormal electrical signals in the brain, which can lead to memory loss.

Findings from a 2018 study indicate that using antiepileptic drugs for over one year significantly increases the risk of Alzheimer’s disease and other types of dementia.

  1. General Anesthesia

Having surgery comes with a host of possible complications, such as infections, blood clots, and nausea. Many people are surprised to learn that postsurgical complications can also include memory problems.

Research on the relationship between general anesthesia and memory problems is mixed, but a paper in Alzheimer’s & Dementia found an increased risk of dementia in people with a history of general anesthesia.

In addition, a before-and-after SPECT study of patients who underwent coronary artery bypass surgery showed that 68% had diminished blood flow, which was linked to decreased verbal and visual memory six months later.

MEMORY RESCUE

If you’re experiencing memory problems and are concerned that it may be related to medication, be aware that there are natural alternatives to anti-anxiety pills, antidepressants, and sleep aids. Be sure to talk to your doctor before stopping any prescription drugs.

In the meantime, get serious about your brain health with memory-boosting lifestyle strategies, including:

  • Eating healthy foods
  • Exercising daily to boost blood flow to the brain
  • Engaging in mental exercise

Adopting a brain-healthy lifestyle worked for Susan, an Amen Clinics patient who called in tears after knee surgery. She said she couldn’t think clearly and was having trouble with her memory. She was convinced she was getting Alzheimer’s disease.

Susan had already had a SPECT scan, but she felt like something had changed and asked for a follow-up scan. Her new brain scan didn’t look healthy. It had a toxic appearance and significantly worse activity in her frontal lobes and temporal lobes, both of which are involved in memory.

It was clear that something bad had happened to her brain since her previous scan. The anesthesia from the surgery and postsurgical painkillers may have contributed to her cognitive decline.

However, by following the brain healthy regimen that is part of the Amen Clinics Memory Rescue program, her memory and thinking improved dramatically. With a brain-based treatment approach, yours can too.

Reviewed by Amen Clinics Inc. Clinicians

We Are Here For You

Memory issues and other mental health conditions can’t wait. At Amen Clinics, we’re here for you. We offer in-clinic brain scanning and appointments, as well as mental telehealth, clinical evaluations, and therapy for adults, teens, children, and couples. Find out more by speaking to a specialist today at 888-288-9834 or visit our contact page here.

Weigand AJ, et al. (2020) Association of anticholinergic medications and AD biomarkers with incidence of MCI among cognitively normal older adults. Neurology, 95 (16) e2295-e2304. https://doi.org/10.1212/WNL.000000000001064

Taipale H, et al. (2018) Use of Antiepileptic Drugs and Dementia Risk—an Analysis of Finnish Health Register and German Health Insurance Data, vol. 66, issue 6, pp 1123-1129. https://doi.org/10.1111/jgs.15358

Schultz, Bob G et al. “The role of statins in both cognitive impairment and protection against dementia: a tale of two mechanisms.” Translational neurodegeneration vol. 7 5. 27 Feb. 2018, doi:10.1186/s40035-018-0110-3

Wang YC, et al. (2018) Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies, https://doi.org/10.1155/2018/5315098

Schiltenwolf, Marcus et al. “Evidence of specific cognitive deficits in patients with chronic low back pain under long-term substitution treatment of opioids.” Pain physician vol. 17,1 (2014): 9-20.

Full, KM et al. Associations of Late-Life Sleep Medication Use With Incident Dementia in the Atherosclerosis Risk in Communities Study, The Journals of Gerontology: Series A, Volume 78, Issue 3, March 2023, Pages 438–446. https://doi.org/10.1093/gerona/glac088

Chen, Chia-Wen et al. “Increased risk of dementia in people with previous exposure to general anesthesia: a nationwide population-based case-control study.” Alzheimer’s & dementia : the journal of the Alzheimer’s Association vol. 10,2 (2014): 196-204. doi:10.1016/j.jalz.2013.05.1766

Efimova, N et al. [Changes in Cerebral Blood Flow and Cognitive Function in Patients Undergoing Coronary Bypass Surgery With Cardiopulmonary Bypass]. Kardiologiia vol. 55,6 (2015): 40-46. https://pubmed.ncbi.nlm.nih.gov/28294781/

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The Pill’s Surprising (and Scary) Effects on the Brain

Research shows that taking birth control pills causes structural changes in the brain, alters neurotransmitter function, and messes with mood regulation.

“The pill” is the most popular form of contraception prescribed in the U.S. with 14% of women aged 15-49 using it. That adds up to over 10 million women. What many of these women don’t know is that in addition to pregnancy prevention, birth control pills can have negative impacts on brain function and mental health.

In fact, a lot of women have misconceptions about how these hormonal contraceptives affect the brain and body and how they influence overall health. It’s time to clear up the confusion.

WHAT ARE ORAL CONTRACEPTIVES?

Oral contraceptives are most commonly associated with preventing pregnancy. However, they are also frequently used to reduce PMS symptoms and other issues that may occur with menstruation, such as:

  • Irregular periods

  • Premenstrual syndrome (PMS)

  • Premenstrual dysphoric disorder (PDD)

  • Painful periods

  • Heavy flow

  • Endometriosis

  • Polycystic ovarian syndrome (PCOS)

  • Fibroids

Because the pill can effectively decrease symptoms of these conditions, it is commonly prescribed.

HOW BIRTH CONTROL PILLS WORK INSIDE THE BODY

Most oral contraceptive pills (OCP) are made with combinations of synthetic estrogen and progestin, a synthetic form of the hormone progesterone. The main goal is preventing ovulation. They have key effects on menstrual cycles.

After taking a birth control pill, these synthetic hormones enter the brain and hijack your cyclical hormonal process. They act as endocrine disruptors, interfering with the signaling process that is necessary for ovulation.

In particular, they prevent the hypothalamus from signaling to the pituitary gland (which regulates your hormones) to release hormones that cause an egg to be released. In the unlikely event ovulation does occur and an egg is fertilized, the synthetic progestin thins the uterine lining, making it more likely that the egg will be shed.

Many birth control pills include a week of placebo pills that induce monthly breakthrough bleeding, but this is not a real menstrual period. It is an artificial pattern that eliminates the natural ebb and flow of estrogen and progesterone throughout the cycle.

You may already be aware that OCPs have been shown to cause problems with blood pressure and blood clots and nearly doubles the risk of strokes, especially if you smoke or have a history of migraine headaches.

But did you know that OCPs also affect your brain and mental wellbeing?

HOW HORMONES WORK IN THE BRAIN

In order to feel happy and healthy, you need to have balanced hormones. Here is some important information to note about the differences between natural and synthetic hormones.

Natural hormones bind to specific receptors and keep your body in balance:

  • Estrogen binds to the estrogen receptor.

  • Progesterone binds to the progesterone receptor.

  • Testosterone binds to the testosterone receptor (yes, women produce testosterone, just not as much as men).

There is no cross-reactivity.

Synthetic progesterone (progestins) acts differently on the body:

  • Progestins do not limit binding to just the progesterone receptor, rather, they bind to many other receptors as well.

  • When a synthetic hormone binds to the wrong receptor, that receptor may convey inaccurate signals, which throws the body off balance. 

Because synthetic hormones may bind to the wrong receptors, birth control pills may cause hormonal imbalances and detrimental side effects. Not all women experience these problems, but for those that do, side effects can be quite miserable.

THE HEAVY TOLL OF THE BIRTH CONTROL PILL ON THE BRAIN

Research shows that taking birth control pills causes structural changes in the brain, alters neurotransmitter function, and messes with mood regulation.

Brain structure: A 2019 study found that the hypothalamus in women taking oral contraceptives was about 6% smaller than in women who weren’t on the pill.

 Impacts neurohormones: Birth control pills also elevate cortisol levels (hello, stress!) and lower testosterone levels (goodbye, sex drive!). And low-testosterone problems can remain even after stopping oral contraceptives, putting you at increased risk for long-term sexual, brain health, and psychiatric disorders.

Microbiome disruption: Synthetic birth control can also disrupt the gut microbiome.

The gut—your gastrointestinal tract (GI)—is often called the second brain because it is lined with about 100 million neurons. That’s more neurons than you have in your spinal cord or in your peripheral nervous system.

Research has shown that gut health problems, such as leaky gut, are associated with mood and anxiety disorders, as well as attention deficit hyperactivity disorder (ADHD), also called attention deficit disorder (ADD).

Micronutrient depletion: Birth control pills interfere with the absorption of essential vitamins and minerals, which can lead to nutritional deficiencies, according to one study.

In particular, key nutrient depletions have been seen in folic acid, B vitamins (B2, B6, and B12), vitamins C and E, and the minerals magnesium, zinc, and selenium—micronutrients that are important for healthy brain function. If you’re taking oral contraceptives, it’s a good idea to take supplements to avoid deficiencies.

SYMPTOMS OF HORMONE IMBALANCES

Often women have no idea that their birth control pills may be causing the following issues:

  • Low moods

  • Mood swings

  • Anxiety

  • Fatigue

  • Low libido

  • Insomnia

  • Weight gain

To find out if your birth control pills are contributing to your symptoms, it’s important to get tested. However, simple standard blood tests will rarely detect this problem.

A better option is a 24-hour urine hormone collection, which is the gold standard for looking at all the hormones and their metabolic byproducts.

An integrative medicine physician, also called a function medicine physician, can be helpful in assessing hormone levels, nutrient deficiencies, and other issues related to hormonal birth control.

THE PILL AND EMOTIONAL HEALTH

For decades, many women have complained the OCPs cause such extreme moodiness and other emotional issues that they quit taking them. Studies back up their claims.

In some women, taking the pill is associated with a wide range of psychiatric issues, including mood disorders like clinical depression, as well as anxiety, fatigue, compulsive behavior, anger, and neurotic symptoms.

Scientists from Denmark found that women ages 15-34 taking OCPs were 23% more likely to start taking antidepressants for the first time than non-OCP users. In fact, studies have shown that bouts of depression have been reported by 16-56% of women on hormonal birth control, which depletes serotonin.

Oral contraceptives also affect mental health indirectly. They put you at greater risk of autoimmune diseases and elevated cortisol levels, both of which are associated with an increased incidence of anxiety and depression.

And as mentioned above, they have also been linked to lower levels of testosterone, which is associated with depression, low libido, and memory problems. And low-testosterone issues can persist after stopping OCPs, meaning you could be facing long-term sexual and mental health problems.

ARE YOU READY TO STOP TAKING BIRTH CONTROL PILLS?

Going off a birth control pill isn’t necessarily a quick-fix solution. Some women experience a rash of symptoms—including mood swings, anxiety, and depression—in the months following cessation of hormonal birth control. Some hormone experts have started calling this effect “post-birth control syndrome.”

In addition, it’s important to remember that if you started taking the pill because you were experiencing irregular periods, fibroids, endometriosis, or other symptoms, the pill doesn’t actually address those issues. It only masks the problem. When you stop taking oral contraceptives, that original issue may return with a vengeance.

If you were experiencing irregularities in your menstrual cycle, note that taking natural progesterone can be quite effective for some women—without any of the side effects of synthetic progestin in hormonal contraceptives.

If you’re taking an oral contraceptive pill to prevent pregnancy, there are other non-synthetic, non-hormonal forms of birth control available that you can discuss with an integrative physician.

HOW TO GET BACK INTO HORMONAL BALANCE 

If you’re taking the pill, here are three strategies to help you regain balance:

1. Take nutritional supplements.

Because OCPs can deplete nutrient absorption, it’s important to supplement your diet with B vitamins (folate, B6 and B12), vitamin E, and magnesium.

2. Don’t stop cold turkey.

Be aware that stopping OCPs isn’t necessarily a quick-fix solution. Some women experience “post-birth control syndrome.” which can cause an array of symptoms—including mood swings, anxiety, and depression—in the months following cessation of hormonal birth control.

If you want to get off OCPs, investigate other types of birth control, such as an intrauterine device (IUD) or barrier methods like condoms or a diaphragm.

3. Test your hormone levels.

If you’re experiencing emotional, psychological, or cognitive symptoms while taking OCPs or after quitting, it’s critical to get a full evaluation that includes testing for any hormonal imbalance. Brain imaging tests can also help determine the root cause of your issues.

If you’ve been taking birth control pills for many years, it can take several months to rebalance your natural hormone levels. This is due to the chronic suppression of your own hormone production. It is often helpful to supplement hormones during this recovery period.

If you must stay on the pill for any particular reason, consider asking your physician about using natural progesterone and/or testosterone to improve quality-of-life issues while taking the pill.

We Are Here For You

Depression, anxiety, and other mental health issues can’t wait. At Amen Clinics, we’re here for you. We offer in-clinic brain scanning and appointments, as well as mental telehealth, clinical evaluations, and therapy for adults, teens, children, and couples. Find out more by speaking to a specialist today at 888-288-9834 or visit our contact page here.

CDC/National Center for Health Statistics. Contraceptive Use. https://www.cdc.gov/nchs/fastats/contraceptive.htm

Loyola University Health System. Increased Stroke Risk From Birth Control Pills, Review Finds. ScienceDaily. October 27, 2009. www.sciencedaily.com/releases/2009/10/091026152820.htm

Williams C. The Pill’ Might Shrink Certain Brain Regions Among Women Taking It. Live Science. December 4, 2019. https://www.livescience.com/birth-control-brain-hypothalamus.html

Skovlund CW, et al. Association of hormonal contraception with depression. JAMA Psychiatry. 2016. 73(11):1154–1162. doi:10.1001/jamapsychiatry.2016.2387

Slap GB. “Oral contraceptives and depression: impact, prevalence and cause.” Journal of Adolescent Health Care: Official Publication of the Society for Adolescent Medicine. 1981. 2(1):53-64. doi:10.1016/s0197-0070(81)80087-3

Hamed K. Risk of inflammatory bowel disease with oral contraceptives and menopausal hormone therapy: Current evidence and future directions. Drug Safety. 2016. 39(3):193-7. doi:10.1007/s40264-015-0372-y

Clapp M, et al. Gut microbiota’s effect on mental health: The gut-brain axis. Clinics and Practice. 2017. 7(4):987. doi:10.4081/cp.2017.987

Palmery M, et al. Oral contraceptives and changes in nutritional requirements. European Review for Medical and Pharmacological Sciences. 2013. 7(3):1804-13. https://pubmed.ncbi.nlm.nih.gov/23852908/

Williams WV. Hormonal contraception and the development of autoimmunity: A review of the literature. The Linacre Quarterly. 2017. 84(3):275-295. doi:10.1080/00243639.2017.1360065

Hertel J, et al. Evidence for stress-like alterations in the HPA-axis in women taking oral contraceptives. Scientific Reports. 2017. 7:14111. https://doi.org/10.1038/s41598-017-13927-7

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Spirituality: How Does It Affect Mental Health?

Developing your sense of spirituality can impact your mental wellness and help you live a more fulfilled life.

In today’s fast-paced world, many people feel a spiritual void—feeling disconnected from themselves, other people, their surroundings, and their purpose in life. Psychiatric research increasingly suggests that a lack of spirituality is associated with increased risk for anxiety, depression, and other mental health conditions. Conversely, having a sense of spirituality enhances mental well-being and cognitive function. Why?

Spirituality doesn’t require that you follow a religion—instead it’s about finding a sense of purpose and connecting with others on something greater than yourself. In fact, a Pew Research Center study found about 41% of U.S. adults say they’ve grown more spiritual over the course of their lifetime, and 24% say they have become more religious.

That’s why understanding what you need can help you feel more connected, happier, and healthier beyond what’s right in front of you. Now, we’ll explore how developing your sense of spirituality can impact your mental wellness and help you live a more fulfilled life.

WHAT DOES SPIRITUALITY MEAN?

First, it’s important to note that spirituality is deeply personal. While some people equate it with religion, spirituality actually extends beyond religious beliefs, according to a 2020 study in Frontiers in Psychology.

It’s also more than your actions—it’s about a sense of connection to yourself, your values, and the world around you. Whether you find spirituality in nature, meditation, or through meaningful relationships, the goal is to use it as a guide to finding purpose, direction, and a sense of belonging.

Spirituality can help you explore your inner self and build a deeper understanding of what truly matters to you…and why. Ultimately, it serves as a foundation for your emotional well-being, personal growth, and mental health long-term.

HOW DOES SPIRITUALITY AFFECT MENTAL HEALTH?

1. Strengthens Your Mind-Body Connection

The connection between the mind and body is profound, and spirituality often serves as the bridge between the two. Spirituality encourages mindfulness and awareness, allowing you to tune into your body’s signals and manage emotions more effectively. This can reduce the symptoms of anxiety, depression, and stress.

According to Dr. Daniel Amen, the founder of Amen Clinics, incorporating mindfulness practices like meditation can enhance cognitive well-being by improving concentration and emotional regulation.

A 2021 study found that meditation actually changes the brain regions related to emotion regulation, increasing self-compassion, mindfulness and meta-cognition. Spirituality enables that mind-body connection that nurtures your emotional health so you can better care for your overall well-being.

2. Enhances Your Cognitive Well-Being and Brain Health

Spiritual fitness is a way to maintain that link between your mental wellness and brain health. You can engage in regular spiritual practices to help improve brain function by reducing stress like:

These activities help lower cortisol levels, a stress hormone known to damage brain cells when elevated for long periods. They also promote the release of neurotransmitters like dopamine and serotonin, which enhance mood and cognitive clarity. Investing time and practice into your spiritual fitness can also enhance neuroplasticity—the brain’s ability to reorganize and adapt to new information.

Enhancing that spiritual connection has been shown to create stronger neural connections and increase activity in the prefrontal cortex—the area of the brain responsible for decision-making, self-awareness, and problem-solving.

By enhancing spiritual fitness, you can improve your cognitive well-being, protect your brain from age-related decline, and boost your ability to think clearly, process emotions, and adapt to new challenges.

3. Gives You a Sense of Connection

One of the most significant ways spirituality affects mental health is through the act of service. Being of service to others creates a sense of purpose and connection—two vital components of mental wellness.

Whether it’s volunteering, helping a friend in need, or simply offering a kind word to a stranger, these acts of kindness can reduce feelings of loneliness and isolation.

Dr. Amen often emphasizes the importance of giving back to others as a way to improve brain health. Studies show that altruism and acts of service are linked to increased happiness, lower stress levels, and even longer lifespans.

Research published in 2023 found that people who volunteered regularly had a lower risk of mortality, reported higher levels of life satisfaction, increased functioning, quality of life, social support, and sense of connection. Findings in a 2022 study in Plos One suggest that when we serve others, we experience bonding, stronger social community, and personal fulfillment that boosts our mental health and fosters a sense of community.

4. Provides Comfort and Promotes Emotional Stability

Having faith in yourself and something bigger than yourself can be a critical part of your mental wellness. Whether through belief in a higher power, the universe, or the natural world, your spirituality can provide the foundation for your faith.

This faith doesn’t have to be religious. Instead, focusing on your belief in the interconnectedness of life and the idea that everything happens for a reason can be sufficient.

Faith in oneself—along with the belief that there is a greater and more positive meaning to life’s challenges—can bring comfort and promote emotional stability. Some research even suggests that it can reduce fear or death anxiety.

This kind of faith also helps people to build resilience and face life’s ups and downs with strength, grace, and compassion. The key is to put your faith into action that positively affects you and those around you in a more meaningful way.

5. Strengthens Your Resilience

Developing a sense of purpose is an essential step in strengthening your resilience and mental well-being. Without it, people often feel lost, unmotivated, and anxious.

Spirituality can help you uncover your unique purpose, whether through work, relationships, or personal growth. Having a clear sense of purpose gives you direction and motivation that enhances your connection with others, cognitive well-being and emotional balance.

One meta-analysis study found that people with a strong sense of purpose in life had a 30% reduced risk of developing cognitive decline as they aged. Additionally, those who live with purpose report lower rates of depression and anxiety. A 2019 UCSD research study confirms that finding meaning in life leads to better health outcomes and increase cognitive functioning.

That said, finding your purpose isn’t a one-size-fits-all journey. It’s a personal process that evolves over time. For some, it may come through serving God or through their career. For others, it might be found in their role as a parent, friend, or community member. In general, it starts by finding the reason within yourself to want to create or be part of something meaningful beyond yourself.

We Are Here For You

Depression, anxiety, and other mental health issues can’t wait. At Amen Clinics, we’re here for you. We offer in-clinic brain scanning and appointments, as well as mental telehealth, clinical evaluations, and therapy for adults, teens, children, and couples. Find out more by speaking to a specialist today at 888-288-9834 or visit our contact page here.

Kallo, A. (2024, January 17). Around 4 in 10 Americans have become more spiritual over time; fewer have become more religious. Pew Research Center. www.pewresearch.org/short-reads/2024/01/17/around-4-in-10-americans-have-become-more-spiritual-over-time-fewer-have-become-more-religious

Bożek, A., Nowak, P. F., & Blukacz, M. (2020). The relationship between spirituality, health-related behavior, and psychological well-being. Frontiers in Psychology, 11, Article 1997. https://doi.org/10.3389/fpsyg.2020.01997

Pascoe, M. C., de Manincor, M., Tseberja, J., Hallgren, M., Baldwin, P. A., & Parker, A. G. (2021). Psychobiological mechanisms underlying the mood benefits of meditation: A narrative review. Comprehensive Psychoneuroendocrinology, 6, 100037. https://doi.org/10.1016/j.cpnec.2021.100037

Eyre, Harris A et al. “A randomized controlled trial of Kundalini yoga in mild cognitive impairment.” International psychogeriatrics vol. 29,4 (2017): 557-567. doi:10.1017/S1041610216002155Wang Y, Tian J, Yang Q. Tai Chi exercise improves working memory capacity and emotion regulation ability. Front Psychol. 2023 Feb 17;14:1047544. doi: 10.3389/fpsyg.2023.1047544. PMID: 36874821; PMCID: PMC9983368.

Weiss-Sidi M, Riemer H. Help others-be happy? The effect of altruistic behavior on happiness across cultures. Front Psychol. 2023 Jun 23;14:1156661. doi: 10.3389/fpsyg.2023.1156661. PMID: 37425146; PMCID: PMC10326385.

Nichol B, Wilson R, Rodrigues A, Haighton C. Exploring the Effects of Volunteering on the Social, Mental, and Physical Health and Well-being of Volunteers: An Umbrella Review. Voluntas. 2023 May 4:1-32. doi: 10.1007/s11266-023-00573-z. Epub ahead of print. PMID: 37360509; PMCID: PMC10159229.

Wickramaratne PJ, Yangchen T, Lepow L, Patra BG, Glicksburg B, Talati A, Adekkanattu P, Ryu E, Biernacka JM, Charney A, Mann JJ, Pathak J, Olfson M, Weissman MM. Social connectedness as a determinant of mental health: A scoping review. PLoS One. 2022 Oct 13;17(10):e0275004. doi: 10.1371/journal.pone.0275004. PMID: 36228007; PMCID: PMC9560615.

Taghiabadi M, Kavosi A, Mirhafez SR, Keshvari M, Mehrabi T. The association between death anxiety with spiritual experiences and life satisfaction in elderly people. Electron Physician. 2017 Mar 25;9(3):3980-3985. doi: 10.19082/3980. PMID: 28461873; PMCID: PMC5407231.

Sutin AR, Aschwanden D, Luchetti M, Stephan Y, Terracciano A. Sense of Purpose in Life Is Associated with Lower Risk of Incident Dementia: A Meta-Analysis. J Alzheimers Dis. 2021;83(1):249-258. doi: 10.3233/JAD-210364. PMID: 34275900; PMCID: PMC8887819.

Brubaker, M. (2019, December 10). Have you found meaning in life? Answer determines health and well-being. UC San Diego. https://today.ucsd.edu/story/have-you-found-meaning-in-life-answer-determines-health-and-well-being

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Are You Tired All the Time Here are 9 Reasons Why

There are many underlying behavioral, cognitive, and psychological causes of fatigue. Some of them may surprise you.

Do you feel like you’re dragging? Too tired to do the things you want to do? Don’t want to get out of bed? Lack the energy to be your best at work, in your relationships, or with your kids?

Being chronically fatigued can really zap your zest for life. It’s no surprise that fatigue impairs physical function, but it also has a negative impact on cognitive ability and emotional control.

Figuring out why you feel drained can be a tiresome effort in itself. Autoimmune disorders such as chronic fatigue syndrome affect anywhere from 836,000 to 2.5 million people in the U.S. But there are many other underlying behavioral, cognitive, and psychological causes of fatigue. Some of them may surprise you.

BEHAVIORAL, COGNITIVE, AND PSYCHOLOGICAL CAUSES OF FATIGUE

  1. Depression

Over 90% of people diagnosed with major depressive disorder experience fatigue, according to a 2018 study in CNS Drugs. In some instances, fatigue may be a side effect of certain medications used to treat depression.

The relationship between depression and tiredness goes both ways, as chronic fatigue also increases the risk for depression.

A 2011 paper in Innovations in Clinical Science reported that depression-related fatigue is associated with myriad effects, including difficulty concentrating, slowed thinking, apathy, boredom, memory problems, increased irritability, emotional disturbance, and a drop in productivity.

Wake-up call: Get moving, even though you may not feel like being active. Research shows that physical exercise has been found to be an effective treatment for mild to moderate depression.

  1. Anxiety

The most common mental health issue, anxiety disorders affect an estimated 40 million Americans. Research shows anxiety and neuroticism, among other conditions, are significantly associated with fatigue.

With anxiety or panic attacks, fears and nervousness can escalate and cause a fight-flight-or-freeze response that triggers the release of a flood of hormones. This can lead to physical reactions, such as a racing heart, shallow breathing, muscle tension, trembling, and more.

When this resolves, it is often followed by feelings of exhaustion. Even in the absence of these high-anxiety moments, ongoing anxiousness can be accompanied by persistent physical and psychological symptoms that drain energy and leave you feeling tired and overwhelmed.

Wake-up call: When you feel anxious or panicky, practice deep breathing to calm your nervous system and induce a sense of relaxation. Understand that relaxation is different from feeling tired.

  1. Seasonal Affective Disorder

Also known as SAD, seasonal affective disorder is a type of depression that occurs seasonally, usually during the winter. Affecting an estimated 6% of Americans, SAD causes increased feelings of fatigue and leads to an additional 2.5 hours of sleep each night in the winter.

People with SAD tend to experience an energy drain, feelings of lethargy, and low motivation.

Wake-up call: Try bright light therapy, which has been found to be beneficial for those with SAD.

  1. Emotional Stress

Stress levels are rising, according to the 2023 Stress in America poll. This annual survey found that the long-term stress of the pandemic has increased mental health conditions, especially among adults aged 35 to 44 (up from 31% in 2019 to 45% in 2023).

Most people can handle life’s everyday stressors without feeling overwhelmed, but when major stresses stack up it can leave you feeling depleted. For example, getting laid off while you’re dealing with a serious health concern can make you feel overtired and emotionally exhausted.

Wake-up call: Practice stress-management techniques, such as meditation or listening to calming music.

  1. Grief

Grief disrupts activity in the limbic system, the brain’s emotional centers, and it can activate the pain centers in the brain resulting in feelings of physical pain. All of this contribute to feelings of exhaustion during the grieving process.

When you’re grieving, you may have trouble sleeping, which leads to daytime drowsiness. You may also feel mentally exhausted as a result of brain overload, as losses often have a wide range of complex implications—such as financial issues, living situations, everyday routines, and more.

Wake-up call: Following a loss, start the healing process as soon as possible and maintain a brain-healthy routine—exercise, nutritious foods, good sleep, and supplements—to preserve energy.

  1. Sleep Disorders

An estimated 50-70 million Americans have some form of sleep disorder, with approximately 10% of Americans suffering from chronic insomnia, and about 22 million diagnosed with sleep apnea.

That’s bad news because a lack of quality rest is a common reason for chronic daytime fatigue. Having trouble falling asleep or staying asleep can have negative consequences, including irritability, brain fog, short temper, trouble concentrating, and more.

Wake-up call: Create a sleep routine that promotes healthy rest and stick with it 7 days a week.

  1. Alcohol or Marijuana Use

Although these compounds initially induce sleepiness for some people, they have the reverse effect as they wear off. This is why you may wake up several hours after you go to sleep—and not be able to return to slumbering.

Alcohol seriously impairs sleep because it disrupts REM sleep, interferes with circadian rhythm, and increases the need for nighttime urination.

A 2022 study found that people who used cannabis on 20 or more days in the past month were more likely to get either too little sleep (less than 6 hours) or too much sleep (more than 9 hours) each night.

Wake-up call: Eliminate or reduce your use of alcohol or marijuana.

  1. Poor Diet

The foods you eat can either energize your brain and body or drain your mental and physical functioning.

Foods that are high-glycemic—think sweets, baked goods, and chips—cause your blood sugar levels to spike then crash, leaving you feeling physically sluggish and mentally dull. Starting your day with doughnuts sets you up for a low-energy day.

Wake-up call: Ditch the high-glycemic foods in favor of more fresh fruits and vegetables. And be sure to eat small amounts of lean protein throughout the day to help keep blood sugar balanced for better energy.

  1. Possible Dementia

Brain-imaging research shows that people aged 50 and older who experience excessive daytime sleepiness and fatigue are at increased risk of developing dementia.

In the participants with high levels of daytime tiredness, brain scans showed detrimental changes in multiple areas of the brain. For example, fatigue was associated with shrinkage in the hippocampus, an area involved in memory formation.

Wake-up call: Identifying which of the 11 major risk factors for memory loss you have and addressing them can be critical to preserving memory as well as improving energy levels.

OVERCOMING FATIGUE

By incorporating these wake-up call strategies, you can reclaim your energy and overcome persistent fatigue. With renewed vitality, you’ll not only feel better but also find yourself more capable of achieving your goals and living the life you desire.

However, if these tips don’t provide the boost you’re looking for, it may be time to consult a healthcare or mental health professional. Understanding the underlying cause of your fatigue is the first step toward addressing it and restoring your energy levels for good.

We Are Here For You

Depression, anxiety, and other mental health issues can’t wait. At Amen Clinics, we’re here for you. We offer in-clinic brain scanning and appointments, as well as mental telehealth, clinical evaluations, and therapy for adults, teens, children, and couples. Find out more by speaking to a specialist today at 888-288-9834 or visit our contact page here.

CDC. Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. May 10, 2024, https://www.cdc.gov/me-cfs/about/index.html

Ghanean, H., Ceniti, A.K. & Kennedy, S.H. Fatigue in Patients with Major Depressive Disorder: Prevalence, Burden and Pharmacological Approaches to Management. CNS Drugs 32, 65–74 (2018). https://doi.org/10.1007/s40263-018-0490-z

Targum, Steven D, and Maurizio Fava. “Fatigue as a residual symptom of depression.” Innovations in clinical neuroscience vol. 8,10 (2011): 40-3.

Carek, Peter J et al. “Exercise for the treatment of depression and anxiety.” International journal of psychiatry in medicine vol. 41,1 (2011): 15-28. doi:10.2190/PM.41.1.c

Vassend, Olav et al. “Fatigue symptoms in relation to neuroticism, anxiety-depression, and musculoskeletal pain. A longitudinal twin study.” PloS one vol. 13,6 e0198594. 7 Jun. 2018, doi:10.1371/journal.pone.0198594

American Psychological Association. Stress in America 2023. https://www.apa.org/news/press/releases/stress/2023/collective-trauma-recovery

Diep C, Tian C, Vachhani K, et alRecent cannabis use and nightly sleep duration in adults: a population analysis of the NHANES from 2005 to 2018Regional Anesthesia & Pain Medicine 2022;47:100-104.

Carvalho, Diego Z et al. “Excessive daytime sleepiness and fatigue may indicate accelerated brain aging in cognitively normal late middle-aged and older adults.” Sleep medicine vol. 32 (2017): 236-243. doi:10.1016/j.sleep.2016.08.023

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