What is Estrogen Dominance?

Blog-What is Estrogen Dominance

Most accurately described as a relative progesterone deficiency. A highly prevalent condition affecting many (if not most) women that we see in our clinics, and across the country.

Hormones – A Balancing Act

Basically, a woman’s menstrual cycle is the ebb and flow of estrogen and progesterone levels throughout the month.

• The first two weeks should be an estrogen dominant phase.
• The last two weeks should be a progesterone dominant phase.

PMS is Due to Estrogen Dominance / Progesterone Deficiency

Sometimes women lack progesterone during the second half of the cycle to counteract estrogenic effects, which leads to premenstrual syndrome (PMS). Some reasons for this deficiency are:

• Genetics
• Being overweight
• Dietary factors
• Environmental toxins

Body fat converts other hormones into estrogen, so the more body fat you have the more estrogen you have. Lack of certain vitamins and nutrients can lead to a decreased breakdown of estrogen, and xenoestrogens in plastics make their way into our food and act as synthetic estrogen, further increasing the estrogenic effect.

Chronic PMS

Nearly all women with symptoms of premenstrual syndrome (PMS) are estrogen dominant. By PMS we mean any unwanted sign or symptom that occurs in the days or weeks prior to starting the menstrual cycle.

PMS Symptoms Include:

• Irritability
• Anxiety
• Depression
• Migraines
• Bloating
• Insomnia
• Abdominal pain and cramps


• A Yin/Yang balance with estrogen. They largely counteract each other’s effects.
• The balance is necessary for the buildup of the uterine lining (estrogen), and then the breakdown and elimination of the lining when no pregnancy occurs (progesterone).
• When the balance is disturbed, PMS and other related problems can occur.

Is PMS Causing You Anxiety or Worsening Your Depression?

Many of the female patients we see at Amen clinics with anxiety or depression have worsening symptoms during the premenstrual time.

The first question we often ask our female patients is: “Do any of the symptoms you have worsen the week before your menstrual cycle starts?” Very often the answer is yes.

Treating PMS with The Amen Clinics Method

In addition to brain SPECT scans and other elements of The Amen Clinics Method that are utilized at Amen Clinics, a thorough hormone evaluation and treatment plan can have a dramatic effect on improving patient outcomes.

You must use natural ‘bioidentical’ progesterone:

• Derived from plant-based sources.
• Converted into actual hormones for greatest bioavailability.
• Available only by prescription.

The synthetic version is not real progesterone, but progestin. This is an entirely different molecule. Virtually all the studies that found adverse effects of hormone use in women (including breast cancer) were due to the use of these synthetic progestins.

Synthetic progestins have been linked to:

• Diabetes,
• high cholesterol,
• fluid retention,
• cancer, and more.

We Can Help

At Amen Clinics, we offer bioidentical hormone replacement therapy (BHRT) as part of our Integrative Medicine program that brings together conventional medicine with complementary and alternative therapies. If you suffer from PMS, hormone replacement therapy may dramatically improve your quality of life. Call us at 888-288-9834 or schedule a visit today.


  1. Dear Dr. Amen and Employees:
    I have followed you for years, Dr. Amen, and bought many books and CDs, etc., mostly from PBS; however, I think you need to become
    current with CBD and endocannabinoids, as well as marijuana usage for pain and other health issues. I agree that it is not something that
    teenagers or young people should use frequently, but I feel that its many attributes and positive uses ought to be acknowledged by you,
    or, you may seem out-dated, on this position.
    Thank you.
    Pamela Murray

    Comment by Pamela — June 11, 2018 @ 10:03 AM

  2. I suffer with PMDD and I’m wondering if Dr. Amen has experience with this condition. I am desperate for help.

    Thank you.

    Comment by Suzanne sahagun — November 11, 2019 @ 9:08 PM

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