Even Happy People Can Get Depressed When Stress and Grief Stack Up
Can you be a happy-go-lucky type of person for most of your life and then fall into depression in mid-life or beyond? Unfortunately, the answer is yes.
Stress is a constant in modern-day life. Deadlines at work, tension in relationships, mounting debt—they all cause stress. But what about when tragedy is added to the mix? Like a loved one is diagnosed with a life-threatening illness, a marriage crumbles, or a pandemic hits. Or do all of them happen at once? When serious setbacks in life are piled on top of everyday stressors, it can be too much to bear, and even typically cheerful people can become depressed.
When serious setbacks in life are piled on top of everyday stressors, it can be too much to bear, and even typically cheerful people can become depressed.
WHEN A SUNNY OUTLOOK SINKS INTO DEPRESSION
This is the situation that actress (“General Hospital” and “The Bold and the Beautiful”) and producer Lilly Melgar found herself in recently. In an episode of Scan My Brain, she explained to clinical psychiatrist Jay Faber, MD, that she’d been through the proverbial wringer in the last few years. After a challenging marriage during which she felt like she was in constant fight-or-flight mode, she lived through what she called “an unnecessarily chaotic divorce.” The experience did a number on her nervous system, leaving her feeling exhausted and drained. As if that wasn’t enough, the night before the pandemic lockdown began in 2020, her former husband took his own life. A month later, Melgar’s father was diagnosed with a life-threatening illness, but she couldn’t be with him due to the quarantine. Not long after that, her beloved dog died too. It was one tragedy after another. It was all too much for Melgar, who says she used to be a happy person by nature. Her usual sunny disposition and drive disappeared, and she says, “I discovered depression, insomnia, and lack of motivation.” To see how the compounded grief and stress were affecting her brain, Melgar visited Amen Clinics for a brain SPECT scan. She was hoping for answers to help her overcome the pain and sadness.STRESS AND GRIEF IN THE BRAIN
Emotional trauma and stress impact the brain in many ways. In many people, stacked stresses, pain, and loss are associated with overactivity in the emotional centers of the brain. Among other findings, that’s what Melgar saw on her own brain scan—overactivity in the basal ganglia, anterior cingulate gyrus, and thalamus (part of the deep limbic system).- Basal ganglia: This set of large structures toward the center of the brain is involved with setting the body’s anxiety When there is too much activity in the basal ganglia, people are more likely to be anxious, nervous, and worried, and they have trouble sleeping.
- Anterior cingulate gyrus (ACG): The ACG is the brain’s gear shifter, which helps you go from thought to thought or from one action to another. When there is overactivity in the ACG, people tend to get stuck on negative thoughts or behaviors.
- Deep limbic system: The limbic system includes the thalamus (involved in relaying information), amygdala (fear center), hippocampus (memory center), hypothalamus (emotional center), and olfactory cortex (sense of smell). Too much activity here is often seen in people with depression.
HOW TO CALM AN OVERACTIVE BRAIN
As Dr. Faber explained to Melgar, with the right strategies, it is possible to calm an overactive brain. Some lifestyle changes that promote calm include:- Nutritional supplements: GABA, magnesium, and lemon balm encourage relaxation.
- Diaphragmatic breathing: Practice deep belly breathing when you feel stressed, anxious, or overwhelmed.
- Calming diet: Eat anti-anxiety foods.
- ANT therapy: Learn to challenge the automatic negative thoughts (ANTs) that make you focus on grief or that increase your stress levels.
- Meditate or try hypnosis: These practices calm stress and anxiety.
- EMDR therapy: EMDR (eye movement desensitization and reprocessing) has been shown to help overcome emotional issues related to trauma.




