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Spect Research

If you search “brain SPECT” in the Library of Medicine Database at www.pubmed.com it will return more than 13,000 scientific citations.

Research has repeatedly recognized the value of brain SPECT—the imaging technology we use with our patients at Amen Clinics—for assessing many different areas of brain function, especially the blood flow patterns in issues such as traumatic brain injury, posttraumatic stress disorder, ADHD, depression, OCD, dementia, substance abuse, autism, seizures, and strokes.

Research at Amen Clinics

Researchers at prestigious institutions that include New York University, UCLA, UC, San Francisco, University of Pennsylvania, Thomas Jefferson University, New York University, and The University of British Columbia, have collaborated with the Amen Clinics Research Team on a wide array of published scientific studies, including:

  • Traumatic brain injury, including our work with veterans and NFL players
  • Posttraumatic stress disorder
  • ADHD
  • Substance abuse, especially marijuana
  • Autism
  • Aging
  • Dementia
  • Depression
  • Anxiety
  • Mania
  • Eating disorders
  • Gender differences
  • Obesity
  • Omega-3 fatty acid differences



In January 2016, Amen Clinics research on distinguishing PTSD from TBI was featured as one of the top 100 stories in science by Discover Magazine.

Our work has been published in prestigious journals, such as the Journal of Alzheimer’s Disease, Molecular Psychiatry, PLOS One, Nature’s Translational Psychiatry, Nature’s Obesity, Journal of Neuropsychiatry and Clinical Neuroscience, Minerva Psichiatrica, Journal of Neurotrauma, American Journal of Psychiatry, Nuclear Medicine Communication, Neurological Research, Journal of the American Academy of Child and Adolescent Psychiatry, Primary Psychiatry, Military Medicine, and General Hospital Psychiatry.

The results of these studies demonstrate the value of brain SPECT imaging for:

  • Evaluating Brain Function
  • Clarifying Diagnoses
  • Guiding Treatment Decisions
  • Measuring the Effectiveness of Treatment Strategies

The Amen Clinics Research Library

Currently, the Amen Clinics’ Research Library contains over 60 peer-reviewed scientific research studies.

The success rate of the Amen Clinics Method, a “whole person” approach to treating psychiatric and behavioral problems, was scientifically validated through a multi-site study that followed 500 complex patients for 6 months.

The clinical history, including biological, psychological, social and spiritual influences as well as brain SPECT imaging were obtained for each patient who was then given an individualized treatment plan tailored to their specific needs.

Well-known, structured clinical assessments measuring important factors such as symptoms, level of depression, and quality of life were administered before starting treatment and again after 6 months.


reported significant clinic improvement after only 6 months when treated with The Amen Clinics Method.


reported an improved quality of life.

The more compliant the study participants were with their treatment plans, the better they felt.

This study is confirmation that even though many patients have tried—but failed—to find answers and relief for symptoms through conventional psychiatry, the Amen Clinics Method offers real solutions and positive outcomes to help patients feel better, more quickly.

Study: https://www.ncbi.nlm.nih.gov/pubmed/?term=AMEN+DG+OUTCOMES

Healthy Surface Rendering

Healthy 3D SPECT, looking at the top 45% of brain perfusion, anything below that level shows up as a hole or a dent.

Healthy Active Rendering

Blue equals average perfusion, red equals the top 15% of perfusion and white is the top 8%.

Toxic Surface Scan

Notice the “Swiss cheese,” shriveled appearance, indicating areas of decreased perfusion.

Trauma Surface Scan

Asymmetrical decreased perfusion left frontal temporal lobe.

Transaxial Slices

Slices 12 and 13 show inverted lobster pattern, associated with ventricular enlargement.

Temporal Lobe Dysfunction

Severe left temporal lobe hypoperfusion shown (arrow) consistent with epilepsy.

Hyperfrontality Active Scan

Severe hyperfrontality (arrow), a pattern consistent with OCD.

Hypofrontality Surface Scan

Low prefrontal cortex perfusion (holes top left image).

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