Let’s Talk About Sex…and Antidepressants

Let’s Talk About Sex…and Antidepressants

Did you know that taking antidepressants can sabotage your sex life? Sexual dysfunction is a common complaint among people taking antidepressants. Research in Drug, Healthcare, and Patient Safety shows that these medications can make you less interested in physical romance, decrease sexual excitement, cause erectile dysfunction and lubrication problems, and make it harder to achieve an orgasm, among other issues.

In turn, this can have a detrimental impact on self-esteem and can lead to relationship problems and marital conflict, which can drive you even deeper into depression.

Many people don’t realize that sexual side effects are common when taking antidepressants and that they can affect both women and men. In some cases, if you’re given a prescription for antidepressants in a brief office visit with a primary care physician or a healthcare provider, you may not be fully informed about these potential side effects. Sexual side effects are a common reason why people with depressive disorder stop taking their medication.

Do All Antidepressants Cause Sexual Side Effects?

Problems in the bedroom can occur with any type of antidepressant, but they are more pronounced with SSRIs (selective serotonin reuptake inhibitors). Common brands of SSRIs include:

  • Zoloft (sertraline)
  • Prozac (fluoxetine)
  • Paxil and Paxil CR (paroxetine)
  • Luvox (fluvoxamine)
  • Lexapro (excitalopram)
  • Cymbalta (culoxetine)
  • Celexa (citalopram)

A review of existing research on antidepressants and sexual dysfunction estimated that as many as 73% of people taking SSRIs experience sexual dysfunction. In one study in the Journal of Sex & Marital Therapy, the frequency of sexual side effects was 65% for paroxetine (Paxil), 59% for fluvoxamine (Luvox), 56% for sertraline (Zoloft), and 54% for fluoxetine (Prozac).

How Do SSRIs Cause Sexual Dysfunction?

First, let’s look at how SSRIs are believed to work in treating depression. These medications enhance the availability of the “don’t worry, be happy” neurotransmitter serotonin, which has been found to be in low levels in people with depression. Low levels of serotonin are also associated with obsessive thinking—the way you might spend every minute of every day thinking about a new love interest. This kind of obsessive thinking is comparable to obsessive-compulsive disorder, which is also characterized by low serotonin levels.

Serotonin-enhancing antidepressants blunt the emotions, including the elation of romance, and suppress obsessive thinking, a critical component of romance.

Brain imaging studies show that SSRIs also calm the anterior cingulate gyrus (where overactivity can cause obsessive thinking) and the basal ganglia (where overactivity is associated with anxiety).

By increasing the availability of serotonin in the brain and by lowering activity in these brain regions, people feel more relaxed, less anxious, and less obsessive. They also feel more blasé when it comes to romance. With a lower libido, you’re less interested in lovemaking.

Saffron: A Pro-Sexual Alternative to Antidepressants

Fortunately, there are alternatives to antidepressants that don’t cause sexual dysfunction. Saffron, a spice from the Crocus sativus flower, is one of them. People have been using saffron, which has over 150 active substances in it, for 2,600 years and it’s been associated with happiness and reduced anxiousness. Scientific research backs this up as more than 20 studies show that saffron is more effective than placebo and equal to the SSRIs Prozac and Zoloft, as well as other antidepressants, such as Effexor and imipramine, for depression.

What makes saffron different is that this natural herb has been found to enhance sexual function. In fact, some call it an aphrodisiac and some women have referred to it as the “Viagra for women.”

A 2018 study in Avicenna Journal of Phytomedicine found that saffron has a positive effect on erectile dysfunction. In a 2012 issue of Human Psychopharmacology: Clinical & Experimental, researchers studied the effects of saffron on women with major depression who were experiencing sexual dysfunction from taking fluoxetine (Prozac). The women in the study taking 30mg of saffron a day for 4 weeks experienced a greater boost in arousal and vaginal lubrication compared to those taking a placebo.

Know the Risks of Antidepressants Before Taking Them

Before taking any medication, it is wise to understand the potential side effects. Taking pills may seem like an easier and quicker solution to bad moods than taking the time and effort to develop brain healthy habits and build skills. But treating one problem only to create another one isn’t smart medicine. A better approach is to look for alternatives to antidepressants and other medications that provide comparable benefits without the unwanted side effects while you work on incorporating brain healthy habits into your life. That’s a win-win for you.

Depression, ADD/ADHD, anxiety, and other mental health issues can’t wait. During these uncertain times, your mental well-being is more important than ever and waiting until life gets back to “normal” is likely to make your symptoms worsen over time.

At Amen Clinics, we’re here for you. We offer in-clinic brain scanning and appointments, as well as mental telehealth, remote clinical evaluations, and video therapy for adults, children, and couples. Find out more by speaking to a specialist today at 888-288-9834. If all our specialists are busy helping others, you can also schedule a time to talk.


  1. I have been on 225mg Effexor for a few years. Can you give me a way to get off of them. I hate the way I feel when I titrate down. I went from 300 mg to 225. I am a very highly sensitive person and without anti depressants I feel deeply. Thank you.

    Comment by Angela Brown — August 1, 2020 @ 2:07 AM

  2. can u take saffron still while using vraylar and or Wellbutrin together

    Comment by dana starr — August 1, 2020 @ 5:17 AM

  3. Angela please look on fb there is a group which helps and supports you to taper off vensir /effexor slowly and safely..just try not to pay alot of attention to the worst cases of people on there as everyone is totally different..but you really need to go slow ..there guidance and support is great

    Comment by Angela please look on fb there is a group which helps and supports you to taper off slowly and safely..just try not to pay alot of attention to the worst cases of people on there as everyone is totally different..but you really need to go slow — August 6, 2020 @ 5:57 PM

  4. 68 years old. Been on antidepressants for around 20 years. Am on cymbalta now. No interest in sex at all and that in itself is depressing. Do I need to taper off completely before starting saffron. I don’t have your book yet so is there a brand that you recommend. Thanks

    Comment by Kathy — September 10, 2023 @ 5:07 PM

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