How Can a Brain SPECT Scan Help Me Get Better Faster?

Brain SPECT Scan

While most psychiatrists continue to diagnose patients based on “symptom clusters”—similar to the way Abraham Lincoln was diagnosed with “melancholia,” or depression, over 150 years ago—a growing number are embracing sophisticated brain imaging technology to aid in the diagnosis and treatment of psychiatric, cognitive, and behavioral issues. A functional brain imaging technology called SPECT (single photon emission computed tomography) has emerged as one of the most helpful tools in clinical practice.

In 2021, the Canadian Association of Nuclear Medicine (CANM) unanimously endorsed SPECT for the assessment of a wide array of issues, including:

  • Neuropsychiatric disorders, such as ADD/ADHD, bipolar disorder, depression, obsessive-compulsive disorder (OCD), and posttraumatic stress disorder (PTSD)
  • Suspected dementia, including Alzheimer’s disease, mild cognitive impairment, vascular dementia, and frontal temporal lobe dementia
  • Substance abuse
  • Traumatic brain injury
  • Strokes

With brain SPECT imaging, the future of psychiatry is here now.

To clarify, a SPECT scan is not a stand-alone diagnosis; the data it provides must be analyzed together with other assessments and pertinent information about a patient. However, by looking at the brain—the organ being treated—this advanced imaging technology can reveal blood flow and activity patterns that align with many different types of mental health disorders. In addition, SPECT scans can help identify the root causes of psychiatric symptoms and prompt physicians to ask better questions to get to the source of those symptoms.


In a nutshell, brain SPECT imaging reveals 3 important things:

  • Areas of the brain that work well
  • Areas of the brain that are overactive, meaning there is abnormally high blood flow
  • Areas of the brain that are underactive, indicating lower than normal blood flow to those areas

The scans can provide valuable information about the biological underpinnings of a person’s symptoms. According to findings from the world’s largest database of more than 200,000 SPECT scans at Amen Clinics, too much or too little activity in different parts of the brain is frequently linked to a wide variety of mental health conditions, including these:


SPECT scans reveal that ADD/ADHD is not a single or simple disorder. Brain scans show there are 7 types of ADD/ADHD and each type has a unique pattern of cerebral blood flow, however, they all share one pattern in common. During concentration, blood flow decreases in the prefrontal cortex, which makes it difficult to stay focused and avoid distractions.


Findings from the scans typically show overactivity in the basal ganglia, which are deep structures in the brain involved with motivation, movement, and setting the body’s “idle.” When they are overactive, it leads to feeling anxious, nervous, and worried, and can cause physical symptoms such as a pounding heart and muscle tension.

Bipolar Disorder:

Although the exact cause of this condition is still not known, it is associated with changes in the function and structure of the brain. SPECT imaging studies have shown that in addition to focal areas of increased activity in the deep limbic system, there is often high activity in other parts of the brain.


Not only can SPECT scans show the specific patterns of the different types of dementia, but it can also identify them years before noticeable symptoms emerge. In Alzheimer’s disease, the temporal and parietal lobes will have lower-than-normal activity, as will the posterior cingulate. In frontotemporal dementia, there will be low blood flow in the frontal and temporal lobes, while in vascular dementia, low blood flow in the areas of the brain that are affected by blood vessel damage will be apparent.


On SPECT scans, a person who is depressed usually has too much overall activity in the deep limbic system, which is the emotional center of the brain. In some cases, depressive symptoms also arise from low blood flow in the frontal lobes, which can make it difficult to put the brakes on negative or sad thoughts and feelings.

SPECT is also helpful in the diagnostic process when depression and anxiety are seen together, which occurs in patients about 75% of the time. Plus, there are 7 types of anxiety and depression, each of which has its own signature pattern and set of symptoms that need different treatment strategies—yet another reason why it is so critical to look at the brain to get a correct diagnosis.

Obsessive-Compulsive Disorder:

With this often-debilitating condition, the scans usually show very high activity in the basal ganglia (described above) and an area called the anterior cingulate gyrus (ACG), which is involved with attention. The increased blood flow to this part of the brain makes it very difficult for people to shift their attention from one thing to the next. Consequently, they get stuck on obsessive thoughts and compulsive rituals.

Interestingly, the overactivity in the ACG can also be seen in some patients who have autism spectrum disorder, people who are very inflexible and rigid, and those with the oppositional defiant disorder.

Posttraumatic Stress Disorder (PTSD):

Whether from childhood trauma, military combat, sexual assault, or other experiences that were life-threatening or felt like it, people suffering from PTSD often have multiple areas in the brain that are overactive. These usually include abnormally high blood flow in the deep limbic system, basal ganglia, and ACG. The overactivity in all of these areas drives many of the distressing symptoms caused by the emotional impact of the trauma.

Traumatic Brain Injury (TBI):

SPECT scans show that nearly 40% of the patients at Amen Clinics have experienced a physical injury to the brain from some type of head trauma. When asked, many people initially don’t remember hitting their head! Injuries from childhood, such as falling out of a tree or crashing on a bike, or concussions from sports, car accidents, and other common causes often get dismissed and forgotten unless they had a cracked skull. Unhealed injuries to the brain can lead to myriad mental health symptoms that can persist for years because they are never properly diagnosed or treated, including:

  • Difficulty with concentration
  • Moodiness
  • Memory problems
  • Depression
  • Anxiety
  • Anger issues
  • Brain fog
  • Poor judgment
  • Impulsivity
  • Risky behavior
  • Addiction

Toxic Exposure:

Similarly, toxins can be harmful to the brain. Again, many people don’t know that they have been or are being exposed to toxic substances that are causing serious problems. On SPECT scans, toxicity shows an overall pattern of decreased activity, affecting many areas of the brain. Among other things, it can be caused by

In addition to psychiatric symptoms such as moodiness, depression, and anxiety, toxic exposure can also cause neurological problems, coordination issues, headaches, confusion, and digestive difficulties.


In all these conditions—and many others—there are symptoms that can overlap with those in other mental health disorders which can make the diagnostic process very difficult. An explosive 2019 study in Psychiatric Research confirms the fact that making psychiatric diagnoses based solely on symptom clusters is scientifically meaningless and disingenuous. The study, led by University of Liverpool researchers, focused on a meticulous analysis of five chapters in the Diagnostic and Statistical Manual (DSM-5): anxiety disorders, depressive disorders, trauma-related disorders, bipolar disorder, and schizophrenia. Their main findings highlight many of the shortcomings of the current diagnostic paradigm:

  • There is a major overlap of symptoms among diagnoses.
  • Many diagnoses overlook the role of psychological trauma and head trauma.
  • The current approach rarely takes the individual in mind.

This study’s deep dive into the numbers shows just how murky and inconsistent the diagnostic model is. For example, “In the DSM-5 there are 270 million combinations of symptoms that would meet the criteria for both PTSD and major depressive disorder, and when five other commonly made diagnoses are seen alongside these two, this figure rises to one quintillion symptom combinations—more than the number of stars in the Milky Way.” Equally concerning is their finding that “two people could receive the same diagnosis without sharing any common symptoms.” The researchers conclude that following a different approach may be more effective than remaining committed to what they called a “disingenuous categorical system.”

Looking at these statistics, it’s not surprising that it can sometimes take years for people to be properly diagnosed and receive effective treatment if a doctor never looks at the brain.

Furthermore, it isn’t uncommon for people to have more than one mental health issue, which is one reason why so many people don’t get better with the treatment they are on. For example, if someone has been diagnosed with ADD/ADHD and given a stimulant medication to help with focus, but they also have undiagnosed anxiety, chances are the medication is going to make them even more anxious, which will make it more difficult to concentrate.

Thus, the technological advances and ability of SPECT to discern subtle differences in brain blood flow patterns allow doctors to make more accurate diagnoses that lead to more effective treatment plans. In turn, this has already helped thousands and thousands of people in the U.S. and around the world avoid prolonged suffering from their symptoms. With SPECT, the future of psychiatry is here now.

ADD, depression, anxiety, and other mental health issues can’t wait. At Amen Clinics, we’re here for you. We offer in-clinic brain scanning and appointments, as well as mental telehealth, clinical evaluations, and therapy for adults, teens, children, and couples. Find out more by speaking to a specialist today at 888-288-9834 or visit our contact page here.


  1. I think I may have experienced brain injury- I have severe ADHD . I also have CPTSD and memory loss issues. Interested to see wgat could be the most help.

    Comment by Heather Bassett — October 20, 2022 @ 3:21 PM

  2. My husband has just been diagnosed with dementia. We live in Springtown, Texas 30 minutes from Dallas/Ft Worth.
    My sister has just been diagnosed with Alzheimer's. She lives in Phoenix, AZ.
    I would like information for both of them.
    Thank you
    Barbara Mercurio

    Comment by Barbara Mercurio — November 18, 2022 @ 1:55 PM

  3. Since I fell, almost two years ago, I am housebound, with an aide 4 days a week and memory lapses. I walk with a walker, am isolated a lot and just want to regain my memory and ability to function as before.

    Comment by Dale R Vani — November 23, 2022 @ 6:22 AM

  4. Does insurance cover the cost of SPECT and if not what is the cost?

    Comment by Kay Fraser — May 1, 2023 @ 4:29 PM

  5. Hello Kay, thank you for reaching out. For more information about brain SPECT scans and our services, please contact our Care Coordinators:

    Comment by Amen Clinics — May 9, 2023 @ 10:42 AM

  6. Please I know a young man who is very much in need for help he is only 27 tried to kill himself 3 times drinking and drugs for years He begs for help to fix himself . Please help before to late

    Comment by — May 13, 2023 @ 5:28 PM

  7. Thank you for reaching out. Our Care Coordinators are available to get you more information by calling or submitting a form on our website:

    If you notice someone making statements about not wanting to be alive, it is a cry for help and should be taken seriously. Or, if a loved one is giving away their belongings, finalizing business matters, or purchasing a weapon or other lethal means, consider it an urgent situation that needs to be addressed immediately by a mental health professional. Call 911 or take the person to the nearest emergency room if you believe they are in crisis.

    If you have concerns for yourself or someone you know, put the National Suicide Prevention Lifeline numbers in your phone directory: 800-273-8255 and 988. It is staffed 24/7 by trained counselors who provide compassionate and knowledgeable support as well as connections to helpful resources.

    Comment by Amen Clinics — May 19, 2023 @ 9:14 AM

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